32046-98-3Relevant academic research and scientific papers
Synthesis of α-fluoroketones and α-fluoroenones in aqueous media
He, Yan,Zhang, Xinying,Shen, Nana,Fan, Xuesen
, p. 9 - 14 (2013)
An efficient synthesis of α-fluoroketones via the nucleophilic fluorination of α-bromoketones in water with TBAF·3H2O as the fluorinating agent was developed in this paper. In addition, a simple and efficient synthesis of α-fluoroenones through the condensation of α-fluoroketones with aldehydes promoted by sodium hydroxide in water was also discovered.
Application of chiral TADDOL ligand and rare earth metal amide in combined catalysis of asymmetric reaction
-
Paragraph 0224-0227, (2020/11/23)
The invention relates to application of chiral TADDOL ligand and rare earth metal amide in combined catalysis of asymmetric epoxidation reaction of chalcone compounds. According to the application, alpha, beta-unsaturated ketone shown in a formula (1) and tert-butyl hydroperoxide react in the presence of organic alkali under the combined catalytic action of a chiral TADDOL ligand shown in a formula (3) and rare earth metal amide in an anhydrous, oxygen-free and protective atmosphere to obtain the chiral epoxy compound shown in the formula (2) after the reaction is completed, wherein R1 is selected from hydrogen, alkyl, halogen, alkoxy, trifluoromethyl, nitro or cyano, R2 is selected from phenyl, substituted phenyl, naphthyl, furyl or thienyl; R3 and R4 are respectively and independently selected from alkyl, phenyl or R3 and R4 and carbon atoms connected with R3 and R4 form naphthenic base; Ar is phenyl, substituted phenyl, biphenyl or naphthyl; the molecular formula of the rare earth metal amide is RE [N (SiMe3) 2] 3. The method has the advantages of wide substrate application range, high yield and high enantioselectivity.
A transition-metal-free, one-pot procedure for the synthesis of α,β-epoxy ketones by oxidative coupling of alkenes and aldehydes via base catalysis
Ke, Qingping,Zhang, Bingyan,Hu, Bolun,Jin, Yangxin,Lu, Guanzhong
supporting information, p. 1012 - 1015 (2015/02/19)
A new strategy for the synthesis of epoxides is presented. This process allows the direct synthesis of epoxides from alkenes and aldehydes through C-H functionalization and C-C/C-O bond formation. This journal is
Study of interactive free energy relationships on oxidation of phenyl styryl ketone and its substituted analogues by pyridinium chlorochromate in acid medium: A kinetic study
Annapoorna,Prasad Rao,Sethuram
, p. 283 - 287 (2007/10/03)
Kinetics of oxidation of phenyl styryl ketones (PSK) by pyridinium chlorochromate (PCC) has been investigated in acetic acid (90% v/v) medium in the presence of HClO4 in the temperature range 322 - 333K. The rate law of the reaction is as follows: -d[PCC]/dt=kK1K2[PSK] [PCC] [H+]/1+K2[PSK] The rates are enhanced by electron-releasing substituents in both the phenyl rings and decreased by electron-withdrawing substituents. The mechanism proposed envisages attack on >C = Cx and qy are found to be 0.236 and 0.252 at 323K.
