13565-37-2

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 122-00-9 para-methylacetophenone 
• 15851-89-5 (E)-p-methylcinnamoyl chloride 
• 108-88-3 toluene 
• 5142-75-6 tri(p-tolyl)bismuth 
• 106-42-3 para-xylene 
• 67-64-1 acetone 
• 589-18-4 4-Methylbenzyl alcohol 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 7163-50-0 (4-methylphenyl)(oxo)acetic acid 
• 766-97-2 4-n-methylphenylacetylene 
• 1866-39-3 4-methylcinnamic acid 

Downstream Products

• 101571-52-2 2,3-dichloro-1,3-di-p-tolyl-propan-1-one 
• 116509-26-3 4-methyl-1,3-bis(4-methylphenyl)-4-nitro-1-pentanone 
• 26957-05-1 1,3-Di-p-tolyl-hexan-1-one 
• 26957-06-2 6-Methyl-1,3-di-p-tolyl-heptan-1-one 
• 26953-31-1 5-Dimethylamino-1,3-di-p-tolyl-pentan-1-one 
• 26957-04-0 6-Dimethylamino-1,3-di-p-tolyl-hexan-1-one 
• 26953-32-2 5-Diethylamino-1,3-di-p-tolyl-pentan-1-one 
• 187158-59-4 5-(4-Methyl-benzoyl)-4-p-tolyl-3,4-dihydro-2H-pyrazole-3-carboxylic acid ethyl ester 
• 74007-51-5 3,3-Dimethoxy-1,2-di-p-tolyl-propan-1-one 
• 691178-81-1 (2R,3S)-4-methylphenyl-3-(4-methylphenyl)-2-oxiranmethanone 
• 727678-36-6 ethyl 2-acetylamino-2-cyano-3-(4-methylphenyl)-5-oxo-5-(4-methylphenyl)pentanoate 
• 849908-86-7 1,3,5-tri-p-tolyl-pentane-1,5-dione 
• 1000619-57-7 3,3-bis(phenylsulfonyl)-1-(4-tolyl)propan-1-one 

Relevant academic research and scientific papers

Antiproliferative effects of chalcones on T cell acute lymphoblastic leukemia-derived cells: Role of PKCβ

In this study, a series of 20 chalcone derivatives was synthesized, and their antiproliferative activity was tested against the human T cell acute lymphoblastic leukemia-derived cell line, CCRF-CEM. On the basis of the structural features of the most active compounds, a new library of chalcone derivatives, according to the structure–activity relationship design, was synthesized, and their antiproliferative activity was tested against the same cancer cell line. Furthermore, four of these derivatives (compounds 3, 4, 8, 28), based on lower IC50 values (between 6.1 and 8.9 μM), were selected for further investigation regarding the modulation of the protein expression of RACK1 (receptor for activated C kinase), protein kinase C (PKC)α and PKCβ, and their action on the cell cycle level. The cell cycle analysis indicated a block in the G0/G1 phase for all four compounds, with a statistically significant decrease in the percentage of cells in the S phase, with no indication of apoptosis (sub-G0/G1 phase). Compounds 4 and 8 showed a statistically significant reduction in the expression of PKCα and an increase in PKCβ, which together with the demonstration of an antiproliferative role of PKCβ, as assessed by treating cells with a selective PKCβ activator, indicated that the observed antiproliferative effect is likely to be mediated through PKCβ induction.

A facile synthesis and properties of multicarbazole molecules containing multiple vinylene bridges

Multibranched π-conjugated materials and hyperbranched polymers have received considerable interest in both academic research and industrial applications because of their unusual molecular structures and properties. In this communication, we provide an efficient approach to synthesize two novel π-conjugated multibranch compounds, which have good solubility and are nanosize (about 5 nm). The double bonds of the multibranch compounds are synthesized using solvent-free Wittig-Horner-Emmons reactions. The reaction conditions are simple and mild. Their optical properties are discussed too. Copyright

Phosphorous Acid Promoted Hydration-Condensation of Aromatic Alkynes with Aldehydes Affording Chalcones in an Oil/Water Two-Phase System

A simple and environmentally benign method was developed for the synthesis of chalcones in high to excellent yields by a phosphorous acid promoted alkyne-aldehyde hydration-condensation in an oil/water two-phase system. The method is the first efficient protocol for the preparation of chalcones that is mediated by a simple Bronsted acid in a two-phase system.

Study of adsorption mechanism of chalcone derivatives on mild steel-sulfuric acid interface

Chalcone derivatives namely: (E)-3-(4-methoxyphenyl)-1-(p-tolyl)prop-2-en-1-one (MTP), (E)-1,3-di-p-tolylprop-2-en-1-one (DTP), and (E)-3-(4-(diethylamino)phenyl)-1-(p-tolyl)prop-2-en-1-one (DEP) were synthesized and characterized by nuclear magnetic reso

Recyclable Copper Nanoparticles-Catalyzed Hydroboration of Alkenes and β-Borylation of α,β-Unsaturated Carbonyl Compounds with Bis(Pinacolato)Diboron

Nano-ferrite-supported Cu nanoparticles (Fe-dopamine-Cu NPs) catalyzed anti-Markovnikov-selective hydroboration of alkenes with B2pin2 is reported under mild reaction conditions. This protocol can be applied to a broad range of substrates with high functional group compatibility. In addition, we demonstrated the use of Fe-dopamine-Cu NPs as a catalyst for the β-borylation of α,β-unsaturated ketones and ester, providing alkylboronate esters in up to 98% yield. Reuse of the magnetically recyclable catalyst resulted in no significant loss of activity in up to five reaction runs for both systems. (Figure presented.).

Heteroleptic copper(I) complexes as energy transfer photocatalysts for the intermolecular [2 + 2] photodimerization of chalcones, cinnamates and cinnamamides

The [2 + 2] photodimerization of chalcones, cinnamates and cinnamamides can be effectively catalyzed by heteroleptic copper(I) complexes. The reactions were carried out under mild reaction conditions and the products were obtained in 20–72% yield under visible light irradiation. The copper-based photocatalyst comprised of the rigid phenanthroline ligand with substituents at the 2,9-positions and the 4,7-positions showed high activity in the photodimerization via an energy transfer pathway.

N-Heterocyclic Carbene Catalyzed Synthesis of Trisubstituted Epoxides via Tandem Amidation/Epoxidation Sequence

A tandem amidation/epoxidation sequence between various substituted chalcones and N,N-dimethylformamide (DMF) for the synthesis of trisubstituted epoxides employing N-heterocyclic carbene catalysis was developed. This reaction was performed under metal-free conditions in the presence of tert-butyl hydroperoxide (TBHP) as the oxidant. Trisubstituted epoxides bearing a ketone and an amide functionality (N,N-dimethyl formyl group) were synthesized starting from a wide range of chalcones in moderate to good yields with excellent diastereoselectivity.

Donor-acceptor fluorophores as efficient energy transfer photocatalysts for [2 + 2] photodimerization

Mild [2 + 2] photodimerization of enone substrates was induced by donor-acceptor fluorophores. Enone substrates were activated efficiently for anti-head to head dimerizations with a high yield (up to 83%) and high selectivity. The adjustable excited state potential also allows donor-acceptor fluorophores to be used for isomerization of the above substrates, confirming the potential of donor-acceptor fluorophores as energy transfer photocatalysts.

H-*BEA Zeolite-Catalyzed Nucleophilic Substitution in Allyl Alcohols Using Sulfonamides, Amides, and Anilines

Herein, we report a novel zeolite-catalyzed nucleophilic substitution in allyl alcohols. The product yield was improved upon the addition of NaOTf (0.05 mol-percent) using the studied zeolites. The highest yields were observed using H-*BEA(Si/Al2 = 40)/NaOTf. The scope of the reaction with respect to the nucleophile was examined using 1,3-diphenylprop-2-ene-1-ol as a model substrate under optimized reaction conditions. p-Substituted aryl sulfonamides bearing electron-rich or electron-deficient substituents, alkyl sulfonamides, and heteroaryl sulfonamides undergo the amidation reaction to produce their corresponding allyl sulfonamides in good yield. Amides and anilines exhibited low activity under the optimized conditions, however, performing the reaction at 90 °C produced the target product. The scope of the allyl alcohol was investigated using p-toluenesulfonamide as the nucleophile and the reaction proceeded with a variety of allylic alcohols. To probe the practical utility of the H-*BEA-catalyzed amidation reaction, a gram-scale reaction was performed using 1.01 g (4.8 mmol) of allyl alcohol, which afforded the target product in 88 percent yield.

Iodine-catalyzed α,β-dehydrogenation of ketones and aldehydes generating conjugated enones and enals

A transition metal-free α,β-dehydrogenation of ketones and aldehydes was developed. This reaction was conducted in a facile I2/KI/DMSO system to produce the corresponding unsaturated compounds in good to high yields. The gram-scale experiment also indicated the potential synthetic value of this new reaction in organic synthesis. In the reaction, DMSO acted as both solvent and mild oxidant.