3206-47-1

Basic information

• Product Name: 1H-Tetrazole, 5-[(1-methylethyl)thio]-1-phenyl-
• CAS NO: 3206-47-1
• Molecular Formula: C10H12N4S
• Molecular Weight: 220.298
• Mol File: 3206-47-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1H-Tetrazole, 5-[(1-methylethyl)thio]-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Tetrazole, 5-[(1-methylethyl)thio]-1-phenyl-(3206-47-1)
• EPA Substance Registry System: 1H-Tetrazole, 5-[(1-methylethyl)thio]-1-phenyl-(3206-47-1)

Safety Data

• Hazardous Substances Data: 3206-47-1(Hazardous Substances Data)

Usage

Structure

Tetrazole ring with a 1-phenyl-5-[(1-methylethyl)thio] substitution

Family

Tetrazole compounds

Use as pharmaceutical intermediate

Synthesizes various drugs

Investigated properties

Biological and pharmacological

Building block

Synthesis of other organic compounds

Precaution

Potential hazards, handle with care

Safety guidelines

Consult safety data sheets and guidelines before use

Upstream product

• 14210-25-4 5-Chloro-1-phenyltetrazole 
• 75-26-3 isopropyl bromide 
• 99418-52-7 isopropyl 2,2,2-trichloroacetimidate 
• 86-93-1 1-Phenyl-1H-tetrazole-5-thiol 
• 67-63-0 isopropyl alcohol 
• 86-93-1 1-phenyl-1H-tetrazole-5-thiol 

Downstream Products

• 3043-64-9 1-phenyl-5-(propane-2-sulfonyl)-pr1H-tetrazole 

Relevant articles and documents

Total Synthesis of the Marine Macrolide Amphidinolide F

A new and efficient convergent approach toward the synthesis of amphidinolide F is described through the assembly of three fragments. The two trans-tetrahydrofurans were built by a diastereoselective C-glycosylation with titanium enolate of bulky N-acetyloxazolidinethiones. The side chain was inserted by a Liebeskind-Srogl cross-coupling reaction. A sulfone condensation/desulfonylation sequence, a Stille cross-coupling, and a macrolactonization were applied to connect the fragments.

A diels-alder approach to (-)-ovalicin

A round at the Oval: The antiangiogenic activity of the natural product ovalicin has sparked significant interest. A highly efficient enantio- and diastereoselective total synthesis of ovalicin proved successful in which the key step involved an endo sele

Tetrazoles. XXXI. Phase-Transfer Reactions of 1-Substituted Tetrazole-5-thiones and Their Derivatives

Alkylation of 1-substituted tetrazole-5-thiones under conditions of phase-transfer catalysis in the two-phase system liquid-liquid proceeds regioselectively at the sulfur atom, regardless of the alkylating agent and phase-transfer catalyst. Phase-transfer oxidation of the 5-alkylthiotetrazoles thus obtained by potassium permanganate is a convenient method for preparation of 5-alkylsulfonyltetrazoles which can be used to synthesize functionally substituted tetrazoles.