32062-69-4

Basic information

• Product Name: 1-(4-bromophenyl)-3-phenylthiourea
• Synonyms: thiourea, N-(4-bromophenyl)-N'-phenyl-
• CAS NO: 32062-69-4
• Molecular Formula: C₁₃H₁₁BrN₂S
• Molecular Weight: 307.2088
• Mol File: 32062-69-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 390.8°C at 760 mmHg
• Flash Point: 190.1°C
• Density: 1.584g/cm³
• Vapor Pressure: 2.58E-06mmHg at 25°C
• Refractive Index: 1.762
• CAS DataBase Reference: 1-(4-bromophenyl)-3-phenylthiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-bromophenyl)-3-phenylthiourea(32062-69-4)
• EPA Substance Registry System: 1-(4-bromophenyl)-3-phenylthiourea(32062-69-4)

Safety Data

• Hazardous Substances Data: 32062-69-4(Hazardous Substances Data)

Usage

General Description

1-(4-bromophenyl)-3-phenylthiourea is a chemical compound with a molecular formula C13H10BrN2S. It is a thiourea derivative, consisting of a phenyl group attached to a thiourea functional group. The compound is commonly used in various research and industrial applications. It is known for its potential biological and pharmacological properties, including anti-inflammatory and antiviral activities. Additionally, it has been studied for its potential use in organic synthesis and as a reagent in chemical reactions. Overall, 1-(4-bromophenyl)-3-phenylthiourea is a versatile chemical compound with a wide range of potential applications in various fields.

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 106-40-1 4-bromo-aniline 
• 62-53-3 aniline 
• 1985-12-2 4-Bromophenyl isothiocyanate 
• 29647-72-1 o-phenyl (4-bromophenyl)carbamothioate 
• 75-15-0 carbon disulfide 

Downstream Products

• 104672-90-4 [3-(4-bromo-phenyl)-thiazolidin-2-ylidene]-phenyl-amine 
• 1017535-57-7 1-acetyl-1-(p-bromophenyl)-3-phenylurea 
• 80529-64-2 Ni(N-phenyl-N'-p-bromophenylthiourea)4(NCS)2 
• 80529-76-6 Cd(N-phenyl-N'-p-bromophenylthiourea)2Cl₂ 
• 80529-78-8 Cd(N-phenyl-N'-p-bromophenylthiourea)4Cl₂ 
• 80529-80-2 Hg(N-phenyl-N'-p-bromophenylthiourea)4(NO₃)2 
• 80529-68-6 Co(N-phenyl-N'-p-bromophenylthiourea)4(NO₃)2 
• 80529-66-4 Co(N-phenyl-N'-p-bromophenylthiourea)2(NCS)2 
• 80529-74-4 Zn(N-phenyl-N'-p-bromophenylthiourea)4(NO₃)2 
• 80529-72-2 Zn(N-phenyl-N'-p-bromophenylthiourea)2Cl₂ 
• 80529-69-7 Fe(N-phenyl-N'-p-bromophenylthiourea)4Cl₂ 
• 80529-65-3 Co(N-phenyl-N'-p-bromophenylthiourea)2Cl₂ 
• 80529-67-5 Co(N-phenyl-N'-p-bromophenylthiourea)4Cl₂ 
• 80529-79-9 Hg(N-phenyl-N'-p-bromophenylthiourea)2Cl₂ 

Relevant articles and documents

Nitroarenes as versatile building blocks for the synthesis of unsymmetrical urea derivatives and N-Arylmethyl-2-substituted benzimidazoles

In this contribution, a fast and simple method for the synthesis of unsymmetrical urea derivatives and N-arylmethyl-2-substituted benzimidazoles was developed starting from nitroarenes. The reaction of nitroarenes and phenyl isocyanate or phenyl isothiocyanate in tin (II) chloride dihydrate/choline chloride eutectic mixture afforded the expected urea and thiourea derivatives, while the reaction of different aldehydes with o-nitroaniline or 4-methoxy-2-nitroaniline shows a markedly high preference for the obtention of N-arylmethyl-2-substituted benzimidazoles over the 2-substituted analogues. This method offers a straightforward alternative to obtain the target compounds in good to excellent yields with short reaction times employing an operationally simple experimental set-up. Graphic abstract: [Figure not available: see fulltext.] A series of unsymmetrical urea and thiourea derivatives together with 1,2-disubstituted benzimidazoles are easily obtained in good yields starting from nitroarenes employing the eutectic mixture tin (II) chloride dihydrate/choline chloride as reductive reaction media.

Nickle Catalysis Enables Access to Thiazolidines from Thioureas via Oxidative Double Isocyanide Insertion Reactions

An efficient synthesis of thiazolidine-2,4,5-triimine derivatives was developed via Ni-catalyzed oxidative double isocyanide insertion to thioureas under air conditions, in which thioureas play three roles as a substrate, a ligand, and overcoming isocyanide polymerization. The reaction is featured by employing a low-cost and low loading Ni(acac)2 catalyst, without any additives, and high atom economy. This is the first example to directly apply a Ni(II) catalyst in oxidative double isocyanide insertion reactions.

Convenient synthesis of unsymmetrical N,N′-disubstituted thioureas in water

A simple and convenient two-step method has been developed and used to synthesise 25 (4 of which are novel) unsymmetrical N,N′-disubstituted thioureas in water. Alkylamines or variously substituted arylamines reacted smoothly with phenyl chlorothionoformate at room temperature to form thiocarbamates, which were then reacted with another alkyl- or arylamine in water at reflux to afford the unsymmetrical N,N′-disubstituted thioureas in good to excellent yields. Mild conditions, simple work-up, high yields as well as using water as solvent are the major advantages of the method.