32065-38-6

Usage

Safety Profile

A poison by an unspecified route. A flammable liquid. When heated to decomposition it emits toxic vapors of NOx and SOx.

InChI:InChI=1/C11H13N3O3S/c1-9-2-4-11(5-3-9)18(16,17)14-7-6-10(15)8-13-12/h2-5,8,14H,6-7H2,1H3/b10-8-

Upstream product

• 42908-33-8 3-{[(4-methylphenyl)sulfonyl]amino}propanoic acid 
• 186581-53-3 diazomethane 
• 61341-03-5 N-(toluene-4-sulfonyl)-β-alanyl chloride 

Downstream Products

• 82125-95-9 4-methyl-N-(3-oxobutyl)benzenesulfonamide 
• 31984-14-2 N-(4-Chloro-3-oxo-butyl)-4-methyl-benzenesulfonamide 
• 73696-28-3 1-[(4-methylphenyl)sulfonyl]pyrrolidin-3-one 
• 10019-95-1 N-tosylpyrrolidinone 
• 118429-43-9 4-[(4-methylphenyl)sulfonylamino]butyric acid methyl ester 

Relevant academic research and scientific papers

Wolff rearrangement of diazo ketones derived from N-p-tolylsulfonyl-protected α- and β-amino acids

Diazo ketones derived from N-p-tolylsulfonyl (tosyl)-protected α- and β-amino acids have been synthesized and their diazo decomposition under standard Wolff rearrangement conditions, PhCO2Ag-Et3N-MeOH, has been investigated. It is observed that, under these conditions, several different reaction pathways, including direct carbene N-H insertion, are possible. The reaction is markedly affected by the N-protecting group, the substrate structure and solvent. For those diazo ketones derived from N-tosyl-protected β-amino acids, the diazo decomposition with anhydrous THF as solvent and PhCO2Ag dissolved in Et3N as catalyst gives the corresponding 5-substituted pyrrolidinones in excellent yields.

PREPARATION OF 1-TOSYL-2- AND 3-PYRROLIDINONES 'VIA' KETENES AND CARBENES

Catalytic decomposition of 1-diazo-4-tosylamino-2-butanone 1a, -2-pentanone 1b, and -2-hexanone 1c, results in the quantitative formation of the 1-tosyl-3-pyrrolidinones 2a, 2b and 2c, while the photolysis afforded the rearranged esters, 3a, 3b and 3c, or

SYNTHESIS AND REACTIONS OF DIAZOCARBONYL COMPOUNDS. I. REACTION OF 1-DIAZO-3-, 1-DIAZO-4-, AND 1-DIAZO-5-PHTHALIMIDOALKAN-2-ONES WITH HYDRAZINE HYDRATE. SYNTHESIS OF 1-DIAZO-3-, 1-DIAZO-4-, AND 1-DIAZO-5-ARENESULFAMOYLALKAN-2-ONES

The reaction of hydrazine hydrate with 1-diazo-3-, 1-diazo-4-, and 1-diazo-5-phthalimidoalkan-2-ones containig a substituent at the α position to the phthalimide group in the hydrocarbon chain leads to the formation of 1-diazo-3- and 1-diazo-4-(2-hydrazid

Antitumor agents: diazomethyl ketone and chloromethyl ketone analogues prepared from N-tosyl amino acids

Diazomethyl ketone and chloromethyl ketone analogues prepared from N-tosyl amino acids have been synthesized and tested for antitumor activity in Ehrlich ascites carcinoma and P-388 lymphocytic leukemia screens in mice. The N-tosyl chloromethyl ketone ana