320776-74-7Relevant academic research and scientific papers
A novel and expedient synthesis of optically active fluoroalkylated amino acids via palladium-catalyzed allylic rearrangement and Ireland-Claisen rearrangement
Konno, Tsutomu,Daitoh, Takeshi,Ishihara, Takashi,Yamanaka, Hiroki
, p. 2743 - 2748 (2001)
The allylic substitution reactions of various chiral α-flouroalkylated mesylates with carboxylic acids in the presence of a palladium catalyst proceeded smoothly to give γ-fluoroalkylated allyl esters in excellent yields. The esters were subsequently subj
Concise syntheses of nonracemic γ-fluoroalkylated allylic alcohols and amines via an enantiospecific palladium-catalyzed allylic substitution reaction
Konno, Tsutomu,Nagata, Kensuke,Ishihara, Takashi,Yamanaka, Hiroki
, p. 1768 - 1775 (2007/10/03)
α-Fluoroalkylated allyl mesylates reacted with various carboxylates and amines in the presence of tetrakis(triphenylphosphine)palladium(0) catalyst to give the corresponding γ-fluoroalkylated (E)-allylic alcohol derivatives and amines, respectively, in excellent yields. In almost all cases, no other regio- and stereoisomers were produced. Application of this palladium-catalyzed allylic substitution reaction to various nonracemic mesylates afforded chiral γ-fluoroalkylated allylic alcohol derivatives and amines without any loss of enantiomeric excess through the reaction.
Highly regio- and stereo-controlled Pd(0)-catalyzed nucleophilic substitution reaction for the synthesis of optically active γ-fluoroalkylated allylic alcohols
Konno,Ishihara,Yamanaka
, p. 8467 - 8472 (2007/10/03)
Pd(0)-catalyzed nucleophilic substitution reaction of optically active α-(fluoroalkyl)allyl mesylates with various types of carboxylates proceeded regioselectively to afford the corresponding chiral γ-fluoroalkylated allylic alcohol derivatives in excellent yields without any loss of optical purities. (C) 2000 Elsevier Science Ltd.
