320776-90-7

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 65-85-0 benzoic acid 
• 122920-69-8 (Z)-hexyl-3-hydroxy-4,4,4-trifluoro-1-butene 
• 111423-32-6 (E)-1-hexyl-3-hydroxy-4,4,4-trifluoro-1-butene 
• 111467-51-7 (S)-(E)-(-)-1-hexyl-3-hydroxy-4,4,4-trifluoro-1-butene 
• 320776-89-4 (1S)-1-(trifluoromethyl)-(2E)-nonenyl methanesulfonate 

Downstream Products

• 1117-86-8 (S)-octane-1,2-diol 

Relevant academic research and scientific papers

Concise syntheses of nonracemic γ-fluoroalkylated allylic alcohols and amines via an enantiospecific palladium-catalyzed allylic substitution reaction

α-Fluoroalkylated allyl mesylates reacted with various carboxylates and amines in the presence of tetrakis(triphenylphosphine)palladium(0) catalyst to give the corresponding γ-fluoroalkylated (E)-allylic alcohol derivatives and amines, respectively, in excellent yields. In almost all cases, no other regio- and stereoisomers were produced. Application of this palladium-catalyzed allylic substitution reaction to various nonracemic mesylates afforded chiral γ-fluoroalkylated allylic alcohol derivatives and amines without any loss of enantiomeric excess through the reaction.

Highly regio- and stereo-controlled Pd(0)-catalyzed nucleophilic substitution reaction for the synthesis of optically active γ-fluoroalkylated allylic alcohols

Pd(0)-catalyzed nucleophilic substitution reaction of optically active α-(fluoroalkyl)allyl mesylates with various types of carboxylates proceeded regioselectively to afford the corresponding chiral γ-fluoroalkylated allylic alcohol derivatives in excellent yields without any loss of optical purities. (C) 2000 Elsevier Science Ltd.