32111-89-0Relevant academic research and scientific papers
HETEROCYCLIC DERIVATIVE HAVING INHIBITORY ACTIVITY ON TYPE-I 11 -HYDROXYSTEROID DEHYDROGENASE
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Page/Page column 43, (2010/08/07)
Disclosed is a compound which is useful as an 11β-hydroxysteroid dehydrogenase type 1 inhibitor. A compound represented by the formula: its pharmaceutically acceptable salt, or a solvate thereof, wherein X is O or S, a broken line and a wavy line represent the presence or the absence of a bond, (i) when a broken line represents the presence of a bond, a wavy line represents the absence of a bond, R2 and R3 are each independently hydrogen, halogen, cyano, hydroxy, carboxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl or the like, (ii) when a broken line represents the absence of a bond, a wavy line represents the presence of a bond, R1 and R4 are each independently hydrogen, halogen or the like, R2 and R3 are each independently hydrogen, halogen, cyano, hydroxy, carboxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl or the like, and R5 and R6 are each independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl or the like.
Acidity and N-methylation of N-aryl-N′-cyanoguanidines
Cunningham, Ian D.,Cox, Brian G.,Wan, Nan Chi,Povey, David C.,Smith, Gallienus W.
, p. 693 - 697 (2007/10/03)
Acid dissociation constants in water have been determined for proton loss from a series of N-aryl-N′-cyanoguanidines 1. Treatment of the same compounds with a strong base, butyllithium, followed by excess methyl iodide leads to successive N-methylation to yield mono-, di- and tri-methylated N-aryl-N′-cyanoguanidines. The mechanism of the methylation is discussed.
