41410-40-6

Usage

Organic compound

It is a carbon-containing compound, which is part of the larger class of chemical compounds known as organic compounds.

Guanidine derivative

The molecule is derived from the guanidine functional group, which is a characteristic feature of 1-cyano-2-(4-methylphenyl)guanidine.

Cyano group presence

The compound contains a cyano group (CN), which is a nitrogen atom triple-bonded to a carbon atom.

4-methylphenyl group presence

The compound also includes a 4-methylphenyl group, which is a phenyl ring (a six-membered aromatic ring) with a methyl group attached at the 4th position.

White to off-white solid

1-cyano-2-(4-methylphenyl)guanidine appears as a white to off-white solid in its pure form.

Sparingly soluble in water

The compound has limited solubility in water, meaning it does not dissolve easily in an aqueous environment.

Pharmaceutical intermediate

It is commonly used as an intermediate in the synthesis of various drugs, aiding in the production of different pharmaceutical compounds.

Antibacterial properties

1-cyano-2-(4-methylphenyl)guanidine has the ability to inhibit or kill bacteria, making it useful in medicinal applications.

Antifungal properties

The compound also exhibits antifungal characteristics, which can help prevent the growth and spread of fungi.

Medicinal and agricultural applications

Due to its antibacterial and antifungal properties, it is a valuable ingredient in various medical and agricultural products.

Potential use as a fuel additive

Researchers have studied the compound for its possible use as an additive in fuel, with the aim of improving combustion efficiency and reducing emissions.

Upstream product

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Downstream Products

• 1158074-30-6 N-[1-({(cyanoimino)[(4-methylphenyl)amino]methyl}amino)-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide 
• 32111-89-0 methyl-p-tolyl-carbamonitrile 
• 522629-97-6 C₁₈H₂₇N₅O₃ 
• 522629-87-4 C₁₆H₂₃N₅O₃ 
• 86320-04-9 N-(4-Oxo-3,4-dihydro-quinazolin-2-yl)-N'-p-tolyl-guanidine 
• 14294-14-5 p-tolylcarbamimidoyl-thiourea 

Relevant academic research and scientific papers

Repurposing N,N'-bis-(arylamidino)-1,4-piperazinedicarboxamidines: An unexpected class of potent inhibitors of cholinesterases

Drug repurposing (=drug repositioning) is an effective way to cut costs for the development of new therapeutics and to reduce the time-to-market time-span. Following this concept a small library of compounds was screened for their ability to act as inhibitors of acetyl- and butyrylcholinesterase. Picloxydine, an established antiseptic, was shown to be an inhibitor for both enzymes. Systematic variation of the aryl substituents led to analogs possessing almost the same good properties as gold standard galantamine hydrobromide.

Discovery and biological evaluation of novel cyanoguanidine P2X7 antagonists with analgesic activity in a rat model of neuropathic pain

We disclose the design of a novel series of cyanoguanidines that are potent (IC50 ? 10-100 nM) and selective (≥100-fold) P2X7 receptor antagonists against the other P2 receptor subtypes such as the P2Y2, P2X4, and P2X3. We also found that these P2X7 antagonists effectively reduced nociception in a rat model of neuropathic pain (Chung model). Particularly, analogue 53 proved to be effective in the Chung model, with an ED50 of 38 μmol/kg after intraperitoneal administration. In addition compound 53 exhibited antiallodynic effects following oral administration and maintained its efficacy following repeated administration in the Chung model. These results suggest an important role of P2X7 receptors in neuropathic pain and therefore a potential use of P2X7 antagonists as novel therapeutic tools for the treatment of this type of pain.