64672-68-0

Basic information

• Product Name: N-Methyl-N-(4-Methylphenyl)aMinoacetonitrile
• Synonyms: N-Methyl-N-(4-Methylphenyl)aMinoacetonitrile;2-(Methyl(p-tolyl)aMino)acetonitrile
• CAS NO: 64672-68-0
• Molecular Formula: C₁₀H₁₂N₂
• Molecular Weight: 160
• Mol File: 64672-68-0.mol
• Article Data: 47

Chemical Properties

• Boiling Point: 156-157℃ (9 Torr)
• Appearance: /
• Density: 1.043±0.06 g/cm3(Predicted)
• PKA: 2.21±0.50(Predicted)
• CAS DataBase Reference: N-Methyl-N-(4-Methylphenyl)aMinoacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methyl-N-(4-Methylphenyl)aMinoacetonitrile(64672-68-0)
• EPA Substance Registry System: N-Methyl-N-(4-Methylphenyl)aMinoacetonitrile(64672-68-0)

Safety Data

• Hazardous Substances Data: 64672-68-0(Hazardous Substances Data)

Upstream product

• 613-90-1 benzoyl cyanide 
• 99-97-8 Dimethyl-p-toluidine 
• 50-00-0 formaldehyd 
• 623-08-5 N-methyl-p-toluidine 
• 7677-24-9 trimethylsilyl cyanide 
• 2739-04-0 N-methyl-N-(4-methylphenyl)formamide 
• 6011-14-9 2-aminoacetonitrile hydrochloride 
• 78-67-1 2,2'-azobis(isobutyronitrile) 
• 106-49-0 p-toluidine 
• 67-56-1 methanol 
• 372-09-8 cyanoacetic acid 
• 333-20-0 potassium thioacyanate 
• 623-49-4 ethyl cyanoformate 
• 140-29-4 phenylacetonitrile 

Downstream Products

• 1664-39-7 N-methyl-N-phenylethylenediamine 

Relevant articles and documents

Iron-catalyzed reductive strecker reaction

Strecker reaction is widely applied for the synthesis of amino acids from aldehydes, amines and cyanides. Herein, we report the FeI2-catalyzed reductive Strecker type reaction of formamides instead of aldehydes to produce amino acetonitriles. The challenging capture of carbinolamine intermediates by CN? was achieved via Fe catalysis. This approach afforded better yields than the use of Ir- or Rh-catalysts. The application ability of this methodology is demonstrated by 1) one-pot construction of (13C labeled) complex molecules from CO2 via amino acetonitrile intermediates and 2) convenient production of homologated carboxylic acids from aldehydes.

Electrochemical strategies for: N -cyanation of secondary amines and α C -cyanation of tertiary amines under transition metal-free conditions

Transition metal-free electrochemical approaches for the N-cyanation of secondary amines and the α C-cyanation of tertiary amines have been well established, with products being obtained in moderate to good yields and with good functional group tolerance under ambient conditions. The synthetic application of the protocols has been highlighted through scale-up experiments in a galvanostatic mode. Preliminary mechanistic investigation has confirmed that TBAB played a critical role in N-cyanation transformation and has indicated that the transformation might proceed via a free radical process. This journal is

Method for preparing alpha-aminonitrile and product and application thereof

The invention discloses a method for preparing alpha-aminonitrile, which comprises the following steps: by using tertiary amine and benzoyl cyanide as reactants, carrying out visible light irradiationin an organic solvent under the condition of oxygen or