32116-24-8Relevant academic research and scientific papers
Synthesis of 5-acetyl-2-aminopyrrole C-deoxyribonucleoside
Oda, Hiroshi,Hanami, Takeshi,Iwashita, Takashi,Kojima, Miki,Itoh, Masayoshi,Hayashizaki, Yoshihide
, p. 12747 - 12753 (2007)
A novel C-deoxyribonucleoside bearing 2-aminopyrrole was synthesized. The C-glycosidation between deoxyribose and pyrrole ring was carried out using palladium-catalyzed Heck coupling in the presence of excess amount of lithium chloride as an additive. The
Design and synthesis of novel pyrimidine analogs as highly selective, non-covalent BTK inhibitors
Kawahata, Wataru,Asami, Tokiko,Irie, Takayuki,Sawa, Masaaki
, p. 145 - 151 (2017/12/06)
BTK is a promising target for the treatment of multiple diseases such as B cell malignances, asthma, and rheumatoid arthritis. Here, we report the discovery of a series of novel pyrimidine analogs as potent, highly selective, non-covalent inhibitors of BTK. Compound 25d demonstrated higher affinity to an unactivated conformation of BTK that resulted in an excellent kinase selectivity. Compound 25d showed a good oral bioavailability in mice, and significantly inhibits the PCA reaction in mice.
Alkaloids from the traditional chinese medicine ChanSu: Synthesis-enabled structural reassignment of bufopyramide to bufoserotonin C
Davison, Emma K.,Sperry, Jonathan
supporting information, p. 7911 - 7914 (2015/07/27)
A synthesis of putative bufopyramide has shown the structure assigned to the natural product to be incorrect. The spectroscopic data for the natural product bufopyramide matches that obtained from a synthetic sample of bufoserotonin C, confirming that the
