1122-10-7

Usage

Uses

Used in Organic Synthesis:
2,3-Dibromomaleinimide is used as a synthetic intermediate for the production of different organic compounds. It is involved in the synthesis of:
1. 2-bromo-3-(1H-indol-3-yl)maleimide:
2,3-Dibromomaleinimide is used as a reactant in the synthesis of 2-bromo-3-(1H-indol-3-yl)maleimide through a reaction with indolyl magnesium bromide in tetrahydrofuran. 2,3-Dibromomaleinimide can be utilized in various chemical and pharmaceutical applications.
2. 2-dibromo-3-propylsulfanyl-maleimide:
In another application, 2,3-dibromomaleinimide is used in the synthesis of 2-dibromo-3-propylsulfanyl-maleimide by reacting with propanethiol and sodium acetate in methanol. This synthesized compound can be employed in various chemical processes and industries.

InChI:InChI=1/C4HBr2NO2/c5-1-2(6)4(9)7-3(1)8/h(H,7,8,9)

Upstream product

• 541-59-3 maleiimide 
• 109-97-7 pyrrole 
• 54705-14-5 2,3,4,5-tetrabromopyrrole 
• 1122-12-9 2,3-dibromomaleic anhydride 
• 57-13-6 urea 
• 952009-55-1 2,5-diacetyl-3,4-dibromo-pyrrole 
• 123-56-8 Succinimide 
• 1003-29-8 2-pyrrole aldehyde 
• 7732-18-5 water 
• 7726-95-6 bromine 
• 7697-37-2 nitric acid 
• 393819-18-6 2-acetyl-3,4,5-tribromopyrrole 
• 32116-24-8 5-acetyl-3-nitro-1H-pyrrole 

Downstream Products

• 119139-23-0 3,4-bis(3-indolyl)-1H-pyrrole-2,5-dione 
• 102147-52-4 N-benzyloxymethyl-3,4-dibromomaleimide 
• 91026-00-5 N-benzyl-2,3-dibromo-maleimide 
• 249763-21-1 2,5-dihydro-3,4-bis(N-phenylsulfonylindol-2-yl)-1H-pyrrole-2,5-dione 
• 569643-26-1 3-bromo-4-[2-(1-methyl-2-phenylthio-1H-imidazol-5-yl)-1H-indol-3-yl]-pyrrole-2,5-dione 
• 1207982-86-2 C₈₀H₁₀₅N₁₉O₂₁S₂ 
• 1334294-52-8 [Pd(N-phenylbenzaldimine(-1H))(μ-2,3-dibromomaleimidato)]2 
• 32774-53-1 3,4-bis(phenylsulfanyl)-2,5-dihydro-1H-pyrrole-2,5-dione 
• 1380307-89-0 3,4-bis((4-bromophenyl)ethynyl)-1H-pyrrole-2,5-dione 
• 1380307-85-6 3,4-bis(phenylethynyl)-1H-pyrrole-2,5-dione 
• 1442447-48-4 3,4-dibromo-2,5-dioxo-2,5-dihydro-pyrrole-1-carboxylic acid methyl ester 
• 40080-10-2 3,4-bis-benzylsulfanyl-pyrrole-2,5-dione 
• 98026-79-0 3-bromo-1H-pyrrole-2,5-dione 

Relevant academic research and scientific papers

A general approach to the synthesis of polyamine linked- monoindolylmaleimides, a new series of trypanothione reductase inhibitors

A simplified approach to the synthesis of 2-polyamine linked- monoindolylmaleimides has been achieved, leading to a new series of trypanothione reductase inhibitors. The conditions of access to N,2- bis(polyamine)-3-monoindolylmaleimides and N,N'-bis(monoindolylmaleimide) polyamines are described. Measured inhibitory activities towards trypanothione reductase from Tryanosoma cruzi show the importance of both aromatic moieties and polyamine chains for trypanothione reductase recognition.

A mild and selective protecting and reversed modification of thiols

One selective thiol-protecting study has been investigated for a wide range of thiols including general thiols and thiols containing multiple functional groups. The reactions of bromomaleimides and thiols under the mild condition afforded the protected products in excellent yields. The thiols can be recovered very quickly using dithiothreitol (DTT) under the mild condition.

Regioselective animation of 3-Bromoindolylmaleimide with amines

3-Bromoindolylmaleimide and bisindolylmaleimide were synthesized from succinimide in three steps sequnence consisting of bromination, N-methylation and indole addition in the presence of magnesium and bromoethane. They were subjeced to the regioselective amination with substituted amines to provide 3-aminoindolylmaleimides, 3- amino-N-alkylated indolylmaleimides and N-alkylated bisindolylmaleimides in good yields. The resulting indolylmaleimides represent a new class of potentially bioactive compounds.

BINOL-fused maleimides - A new class of C2-symmetric chiral imides

The first synthesis of BINOL-fused maleimides has been developed. This new chiral scaffold is easily accessible from various BINOL analogues and 2,3-dihalomaleimide derivatives under basic conditions. It can be easily functionalized on the BINOL moiety an

Synthesis and cytotoxicity of novel 3-amino-4-indolylmaleimide derivatives

In an attempt to develop potent and selective antitumor agents, a series of novel 3-amino-4- indolylmaleimides were designed and synthesized. The reaction showed high regioselectivity. The structure of compound 7a was determined by an X-ray single crystal

Synthesis and cytotoxicity of novel 3-amido-4-indolylmaleimide derivatives

A series of novel 3-amido-4-indolylmaleimides have been synthesised from succinimide in five steps sequence consisting of bromination, indole addition, azide substitution, reduction and selective acylation. Cytotoxicity was evaluated for the products agai

Synthesis of substituted bis(heteroaryl)maleimides

Substituted bis(fur-2-yl), bis(fur-3-yl) and bis(thien-2-yl) maleimides with potential antidiabetic properties are described. Their synthesis involves, as a key step, a Suzuki cross-coupling between various boron derivatives and the diiodomaleimides. Therefore, a wide range of substituted symmetric and non-symmetric maleimide derivatives can be prepared.