32117-05-8

Upstream product

• 14719-83-6 methyl 3-nitro-4-chlorobenzoate 
• 110-89-4 piperidine 
• 2363-16-8 methyl 4-bromo-3-nitrobenzoate 
• 89976-27-2 methyl ester of 4-iodo-3-nitrobenzoic acid 
• 67-56-1 methanol 
• 350671-38-4 5-Ethyl-5-[4-(4-piperidino-3-nitrobenzoyl)oxymethylbenzyl]barbituric acid 
• 105-45-3 acetoacetic acid methyl ester 
• 453-71-4 3-nitro-4-fluorobenzoic acid 
• 10338-58-6 N-(4-[methyl 4-benzoxycarbonyl])piperidine 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 329-59-9 4-fluoro-3-nitro-benzoic acid methyl ester 

Downstream Products

• 1131614-63-5 C₁₃H₁₆INO₂ 
• 696616-81-6 3-Amino-4-piperidino-benzoesaeuremethylester 

Relevant academic research and scientific papers

PIFA-Promoted, Solvent-Controlled Selective Functionalization of C(sp2)-H or C(sp3)-H: Nitration via C-N Bond Cleavage of CH3NO2, Cyanation, or Oxygenation in Water

A novel nitration (via C(sp3)-N breaking/C(sp2)-N formation with CH3NO2) mediated by [bis(trifluoroacetoxy)iodo]benzene (PIFA) is described. The NO2 transfer from CH3NO2 to the aromatic group of the substrate is possible with careful selection of the solvent, NaX, and oxidant. In addition, the solvent-controlled C(sp2)-H functionalization can shift to an α-C(sp3)-H functionalization (cyanation or oxygenation) of the α-C(sp3)-H of cyclic amines.

BENZAMIDE AND NICOTINAMIDE COMPOUNDS AND METHODS OF USING SAME

The present disclosure provides benzamide and nicotinamide compounds and pharmaceutical uses of the compounds. The compounds can be used to treat, for example, cancers such hematopoietic cancers (e.g., leukemia). The preferred compounds of the invention c

An unexpected [1,5]-H shift in the synthesis of nitroanilines

Equation Presented Addition of methyl acetoacetate to 2-nitrovinamidinium hexafluorophosphate salts leads to the formation of anilines or phenols in good to excellent yields depending on the alkylamine substituents. Small substituents, e.g., pyrrolidine,

Synthesis based on affinity separation (SAS): Separation of products having barbituric acid tag from untagged compounds by using hydrogen bond interaction

A new method is described for affinity purification of synthetic compounds based on molecular recognition between bis(2,6-diaminopyridine)amide of isophthalic acid and a barbituric acid derivative. The desired compounds possessing the barbituric acid deri

Nucleophilic Substitution Reactions of 1-Halogeno-4-COR-2-nitrobenzenes and 1-Halogeno-6-COR-2-nitrobenzenes with Sodium Benzenethiolate and Piperidine. Can an "Inverted Built-in Solvation" Be Responsible for the Peculiar Activation by an o-Carboxamido Group in SNAr Reactions with an Anionic Nucleophile?

A kinetic study of the title reactions has allowed an interpretation of the higher efficiency of an o-carboxamido group with respect to an o-carbomethoxy group in activating the benzenethiolate-dehalogenation reactions in methanol (kCONH2/kCO2Me 2.2-3.0) as due to an interaction between the anionic nucleophile and the hydrogen atoms of the carboxamido group. An inversion of the activating power of the two groups (kCONH2/kCO2Me 0.14) in the reactions with the same nucleophile has been observed when they are in a para-position. Moreover, for piperidino-dehalogenation reactions in methanol kCONH2/kCO2Me ratios less than unity (0.2-0.6) have been observed independently of the position (ortho or para) of the carboxamido and carbomethoxy groups with respect to the reaction center.