321535-23-3

Basic information

• Product Name: 6-IODO-2,3-DIMETHOXYPYRIDINE
• Synonyms: 6-IODO-2,3-DIMETHOXYPYRIDINE;2,3-Dimethoxy-6-iodopyridine
• CAS NO: 321535-23-3
• Molecular Formula: C₇H₈INO₂
• Molecular Weight: 265.05
• EINECS: 200-258-5
• Mol File: 321535-23-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 274.7 °C at 760 mmHg
• Flash Point: 119.9 °C
• Appearance: /
• Density: 1.735 g/cm³
• Storage Temp.: 2-8°C
• PKA: -1.30±0.10(Predicted)
• CAS DataBase Reference: 6-IODO-2,3-DIMETHOXYPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-IODO-2,3-DIMETHOXYPYRIDINE(321535-23-3)
• EPA Substance Registry System: 6-IODO-2,3-DIMETHOXYPYRIDINE(321535-23-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 321535-23-3(Hazardous Substances Data)

Usage

General Description

6-Iodo-2,3-dimethoxypyridine is a chemical compound with the molecular formula C7H8INO2. It is a derivative of pyridine with two methoxy groups and one iodo group attached to the pyridine ring. 6-Iodo-2,3-dimethoxypyridine is mainly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has also been reported to have potential applications in organic synthesis and medicinal chemistry. 6-Iodo-2,3-dimethoxypyridine has been studied for its reactivity and potential biological activities, making it a valuable compound in the field of chemical research and development.

InChI:InChI=1S/C7H8INO2/c1-10-5-3-4-6(8)9-7(5)11-2/h3-4H,1-2H3

Upstream product

• 67-56-1 methanol 
• 124-41-4 sodium methylate 
• 321535-37-9 2-bromo-6-iodo-3-methoxypyridine 

Downstream Products

• 106331-68-4 5,6-dimethoxypicolinaldehyde 
• 910616-72-7 3-chloro-2-iodo-5,6-dimethoxypyridine 
• 1431710-13-2 3-chloro-5,6-dimethoxypyridine-2-carbonitrile 
• 324028-89-9 5,6-dimethoxy-2-picolinic acid 
• 1300587-96-5 C₁₉H₂₆N₂O₂ 
• 1300587-57-8 N-[2-(5,6-dimethoxy-2-pyridinyl)ethyl]-6-methyl-N-(1-methyl-3-phenylpropyl)-2-pyridinecarboxamide 
• 1260613-20-4 (2R)-2-[(5S)-2,3-dimethoxy-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]-N-methyl-2-phenylethanamide 
• 1260613-19-1 2,3-dimethoxy-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-5,6,7,8-tetrahydro-1,6-naphthyridine 
• 1260613-18-0 2,3-dimethoxy-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-7,8-dihydro-1,6-naphthyridine 
• 1260613-17-9 N-[2-(5,6-dimethoxy-2-pyridinyl)ethyl]-3-[4-(trifluoromethyl)phenyl]propanamide 
• 1112851-50-9 5,6-dimethoxypyridine-2-carbonitrile 
• 1112850-40-4 (5,6-dimethoxypyridin-2-yl)methanamine 
• 1417710-71-4 6-(benzylsulfanyl)-2,3-dimethoxypyridine 
• 1417710-29-2 6-(benzylsulfanyl)-3-hydroxypyridin-2(1H)-one 

Relevant articles and documents

BCL-2 INHIBITOR

Disclosed herein is a compound of Formula (I) for inhibiting both Bcl-2 wild type and mutated Bcl-2, in particular, Bcl-2 G101V and D103Y, and a method of using the compound disclosed herein for treating dysregulated apoptotic diseases.

Design of potent IGF1-R inhibitors related to bis-azaindoles

From an azaindole lead, identified in high throughput screen, a series of potent bis-azaindole inhibitors of IGF1-R have been synthesized using rational drug design and SAR based on a in silico binding mode hypothesis. Although the resulting compounds produced the expected improved potency, the model was not validated by the co-crystallization experiments with IGF1-R.

ISONICOTINAMIDE OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to isonicotinamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. Th