321547-37-9

Upstream product

• 1376708-67-6 C₉H₆ClNO₂S₂ 
• 768-60-5 4-methoxyphenylacetylen 
• 149-30-4 2-Mercaptobenzothiazole 
• 2516-40-7 2-bromo-1,3-benzothiazole 
• 123-11-5 4-methoxy-benzaldehyde 
• 60512-57-4 1-(2,2-dibromovinyl)-4-methoxybenzene 
• 95-16-9 1,3-Benzothiazole 
• 1123-99-5 2-iodobenzothiazole 

Relevant academic research and scientific papers

CuI assisted desulfurative Sonogashira reaction of mercapto N-heterocyclic derivatives with alkynes

A palladium catalyzed Sonogashira reaction of mercapto N-heterocyclic derivatives with terminal alkynes by using CuI as the desulfurative reagent was described in this report. It provided an effective strategy for obtaining sp-sp2 cross-coupling products in good yields. The reaction mechanism was also investigated by density functional theory (DFT) calculation.

Method for preparing C2-position alkynyl compound by catalyzing thiamine type compound desulfuration through cuprous halides

The invention provides a method for efficiently synthesizing derivatives which contain different substitution functional groups and have C2-position alkynyl substituted.According to the method, Pd(OAc)2(PPh3)2/CuI is used as a catalyst, Na2CO3 is added as alkaline, compounds containing thiamine and terminal alkyne are used as oligomer, and organic solvent is added to the reaction system.The method has the advantages that the catalyst is low in price and easy to obtain; the reaction condition is mild, safe and reliable; the highest yield of target products reaches 92%.The method overcomes the defects that in traditional desulfuration reaction, cuprous thiophene needs to be used as a desulfurizing agent and cuprous halides can not react; the operation process is simple, and good industrial application prospects are achieved.

Synthesis of internal alkynes through the Pd-catalyzed coupling of heteroaryl halides with terminal alkynes

Sonogashira-type cross-couplings of functionalized heterocyclic halides with terminal alkynes were performed efficiently at room temperature. The heteroaryl halides were easily prepared from the corresponding heterocyclic compounds. The catalytic system tolerated a very broad scope of substrates; oxazoles, thiazoles, and furans participate in this type of reaction for the first time. This reaction provides an efficient method for the direct functionalization of heterocycles. Sonogashira-type cross-coupling of functionalized heterocyclic halides with terminal alkynes are performed efficiently at room temperature. The catalytic system tolerates a very broad scope of substrates; oxazoles, thiazoles, and furans participate in this type of reaction for the first time. The reaction provides an efficient method for the direct functionalization of heterocycles. Copyright

A highly stereoselective synthesis of E-(but-1-en-3-yne-1-sulfonyl) hetarenes and disubstituted 2-benzothiazolyl alkynes by palladium catalyzed sonogashira type coupling of 2-chlorovinylsulfones

Abstract: Novel and highly stereoselective route to E-(but-1-en-3-yne-1- sulfonyl)hetarenes by palladium catalyzed Sonogashira type coupling of unstable E-2-chlorovinylsulfonylbenzene and E-2-(2-chlorovinylsulfonyl)pyridine was presented. Usage of potassium phosphate as novel base in Sonogashira reaction was demonstrated. Unusual coupling products in the Sonogashira reaction of E-2-(2-chlorovinylsulfanyl)benzothiazole with different alkynes were obtained.

Synthesis and antimicrobial activity of new 2-phenylethynylbenzothiazoles and related salts

New 2-phenylethynylbenzothiazoles were synthesized by coupling reaction between 2-iodobenzothiazole and substituted phenylacetylenes under palladium catalysis. The modified Wittig reaction was used to prepare the substituted phenylacetylenes from correspo