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321574-99-6

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321574-99-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 321574-99-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,1,5,7 and 4 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 321574-99:
(8*3)+(7*2)+(6*1)+(5*5)+(4*7)+(3*4)+(2*9)+(1*9)=136
136 % 10 = 6
So 321574-99-6 is a valid CAS Registry Number.

321574-99-6Relevant articles and documents

Azolidines as beta-3 adrenergic receptor agonists

-

, (2008/06/13)

This invention provides compounds of Formula I having the structure wherein, A, X, Y, Z, W, R1, R2, R3, R4, R5, and R6 are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.

Potent, selective benzenesulfonamide agonists of the human β3 adrenergic receptor

Weber, Ann E.,Mathvink, Robert J.,Perkins, Leroy,Hutchins, Jennifer E.,Candelore, Mari R.,Tota, Laurie,Strader, Catherine D.,Wyvratt, Matthew J.,Fisher, Michael H.

, p. 1101 - 1106 (2007/10/03)

A cloned human β3 adrenergic receptor assay was used to identify phenoxypropanolamine agonist 1. SAR, studies led to the identification of benzenesulfonamide derivative 20, a 6.3 nM β3 agonist which shows 30-fold selectivity for β3 agonist activity over β1 and β2 receptor binding. Further refinement of this lead provided 4-bromo derivative 39, a subnanomolar agonist with 660-fold and 230-fold selectivity over β1 and β2, respectively.

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