3216-49-7

Usage

Uses

Used in Pharmaceutical Industry:
3-Methyl-1-benzothiophene-2-carbonitrile is used as an intermediate in the production of active pharmaceutical ingredients (APIs) for its role in the synthesis of various organic compounds.
Used in Agrochemical Industry:
3-Methyl-1-benzothiophene-2-carbonitrile is used as a precursor for the synthesis of agrochemicals, contributing to the development of effective and sustainable solutions for agriculture.
Used in Dye and Pigment Manufacturing:
3-Methyl-1-benzothiophene-2-carbonitrile is used as a key component in the manufacturing of dyes and pigments, enabling the creation of a wide range of colors and shades for various applications.
Used in Specialty Chemicals Production:
3-Methyl-1-benzothiophene-2-carbonitrile is utilized in the production of specialty chemicals, where its unique properties contribute to the development of innovative and high-performance products.

InChI:InChI=1/C10H7NS/c1-7-8-4-2-3-5-9(8)12-10(7)6-11/h2-5H,1H3

Upstream product

• 67-56-1 methanol 
• 1455-18-1 3-methylbenzothiophene 
• 143-33-9 sodium cyanide 
• 22053-74-3 3-methylbenzo[b]thiophene-2-carboxaldehyde 
• 773837-37-9 sodium cyanide 
• 3133-78-6 3-methylbenzo[b]thiophene-2-carboxylic acid 
• 109-77-3 malononitrile 
• 13472-08-7 azobis(2-cyanobutane) 

Relevant academic research and scientific papers

Conversions of aryl carboxylic acids into aryl nitriles using multiple types of Cu-mediated decarboxylative cyanation under aerobic conditions

Here, we used malononitrile or AMBN as a cyanating agent to develop efficient and practical protocols for Cu-mediated decarboxylative cyanations, under aerobic conditions, of aryl carboxylic acids bearing nitro and methoxyl substituents at the ortho position as well as of heteroaromatic carboxylic acids. These protocols involved economical methods to synthesize value-added aryl nitriles from simple and inexpensive raw materials. Further diversification of the 2-nitrobenzonitrile product was performed to highlight the practicality of the protocols. This journal is

Electrochemical C-H cyanation of electron-rich (Hetero)arenes

A straightforward method for the electrochemical C-H cyanation of arenes and heteroarenes that proceeds at room temperature in MeOH, with NaCN as the reagent in a simple, open, undivided electrochemical cell is reported. The platinum electrodes are passivated by ad-sorbed cyanide, which allows conversion of an exceptionally broad range of electron-rich substrates all the way down to dialkyl arenes. The cyanide electrolyte can be replenished with HCN, opening opportunities for salt-free industrial C-H cyanation.

Stable and reusable nanoscale Fe2O3-catalyzed aerobic oxidation process for the selective synthesis of nitriles and primary amides

The sustainable introduction of nitrogen moieties in the form of nitrile or amide groups in functionalized molecules is of fundamental interest because nitrogen-containing motifs are found in a large number of life science molecules, natural products and materials. Hence, the synthesis and functionalization of nitriles and amides from easily available starting materials using cost-effective catalysts and green reagents is highly desired. In this regard, herein we report the nanoscale iron oxide-catalyzed environmentally benign synthesis of nitriles and primary amides from aldehydes and aqueous ammonia in the presence of 1 bar O2 or air. Under mild reaction conditions, this iron-catalyzed aerobic oxidation process proceeds to synthesise functionalized and structurally diverse aromatic, aliphatic and heterocyclic nitriles. Additionally, applying this iron-based protocol, primary amides have also been prepared in a water medium.

Anodic Cyanation of Benzothiophenes

The electrooxidation of benzothiophene and 2-methyl- and 3-methyl-benzothiophene was carried out in methanol containing sodium cyanide at a Pt anode in a divided cell.In all instances, heterocyclic ring-substitution products were obtained, together with minor amounts of addition products.With methylbenzothiophene, a small amount of side-chain-methoxylation product was also formed as a by-product.