321691-00-3

Upstream product

• 542-08-5 isopropyl acetoacetate 
• 100-52-7 benzaldehyde 
• 17356-08-0 thiourea 

Downstream Products

• 1390620-56-0 isopropyl 2-(4-tert-butylbenzylidene)-5-methyl-3-oxo-7-phenyl-3,7-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 1390620-51-5 isopropyl 2-(4-methylbenzylidene)-5-methyl-3-oxo-7-phenyl-3,7-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 1390620-54-8 isopropyl 2-(4-chlorobenzylidene)-5-methyl-3-oxo-7-phenyl-3,7-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 1390620-57-1 isopropyl 2-(4-nitrobenzylidene)-5-methyl-3-oxo-7-phenyl-3,7-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 1390620-48-0 isopropyl 2-benzylidene-5-methyl-3-oxo-7-phenyl-3,7-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 1390620-52-6 isopropyl 2-(4-methoxybenzylidene)-5-methyl-3-oxo-7-phenyl-3,7-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 1390620-49-1 isopropyl 2-(4-bromobenzylidene)-5-methyl-3-oxo-7-phenyl-3,7-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 1390620-53-7 isopropyl 2-(4-(dimethylamino)benzylidene)-5-methyl-3-oxo-7-phenyl-3,7-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 1390620-50-4 isopropyl 2-(4-ethylbenzylidene)-5-methyl-3-oxo-7-phenyl-3,7-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 1390620-55-9 isopropyl 2-(4-isopropylbenzylidene)-5-methyl-3-oxo-7-phenyl-3,7-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 1421502-24-0 isopropyl 2-(benzylthio)-6-methyl-4-phenyl-1,4-dihydropyrimidine-5-carboxylate 
• 1421502-25-1 isopropyl 2-(4-bromobenzylthio)-6-methyl-4-phenyl-1,4-dihydropyrimidine-5-carboxylate 
• 1421502-27-3 isopropyl 2-(4-ethylbenzylthio)-6-methyl-4-phenyl-1,4-dihydropyrimidine-5-carboxylate 
• 1421502-29-5 isopropyl 6-methyl-2-(4-methylbenzylthio)-4-phenyl-1,4-dihydropyrimidine-5-carboxylate 

Relevant academic research and scientific papers

UV-Light-Irradiated Trifluoromethylation of Diheteroaryl Disulfides with CF3SO2Na

A simple protocol for the UV light irradiated preparation of heteroaryl trifluoromethyl thioethers from disulfides and inexpensive, environmentally sodium triflinate (CF3SO2Na) has been developed. The features of simple and clean rea

Metal-Free Visible-Light-Mediated Desulfurization and Aromatization of Dihydropyrimidine-2-thiones for Synthesis of 2-Unsubstituted Pyrimidines

The visible-light-mediated aerobic desulfurization and aromatization of Biginelli 3,4-dihydropyrimidine-2(1H)-thiones for a one-step synthesis of 2-unsubstituted pyrimidines was established. The protocol uses molecular oxygen as an inexpensive oxidant, wi

A domino desulfitative coupling and decarboxylative coupling of 3,4-dihydropyrimidine-2-thiones with copper(I) carboxylates

A novel and general carbon-nitrogen and carbon-carbon cross-coupling reaction between 3,4-dihydropyrimidine-2-thiones and copper(I) carboxylates were performed in the presence of palladium acetate. The copper(I) carboxylates act not only as desulfurative

Dehydrosulfurative C-N Cross-Coupling and Concomitant Oxidative Dehydrogenation for One-Step Synthesis of 2-Aryl(alkyl)aminopyrimidines from 3,4-Dihydropyrimidin-1H-2-thiones

A method for the synthesis of 2-aryl(alkyl)aminopyrimidines from readily available 3,4-dihydropyrimidin-1H-2-thiones (DHPMs) via dehydrosulfurative C-N cross-coupling and concomitant oxidative dehydrogenation under a Pd/Cu catalytic system is described. This reaction protocol provides unprecedented diversity of fully substituted 2-aryl(alkyl)aminopyrimidines in a single step from a wide range of DHPMs and amine coupling partners.

Synthesis and biological evaluation of novel thio-1,4-dihydropyrimidine-5- carboxylate derivatives

We have synthesized ten novel isopropyl 2-(4-substituted benzylthio)-6-methyl-4-phenyl-1,4-dihydropyrimidine-5-carboxylate derivatives (5a-j). All the synthesized compounds were characterized by 1H NMR, 13C NMR, IR, MS and elemental analysis data. Newly synthesized compounds were screened for antiinflammatory activity on acetic acid induced writhing in mice and carrageenan induced paw oedema in rats. Compounds (5g) and (5b) showed a potent antiinflammatory activity (100 % at 100 mg/kg b.w) compared to reference standard drug, nimesulide (100% at 50 mg/kg b.w). The other compounds showed good antiinflammatory activity. All the synthesized compounds were also screened for antioxidant activity, among those three compounds were shown good antioxidant activity by using the in vitro method.

Synthesis and biological evaluation of novel isopropyl 2- thiazolopyrimidine-6-carboxylate derivatives

In the present study, we have synthesized novel Isopropyl 2-(4-substitutedbenzylidene)-5-methyl-3-oxo-7-phenyl-3,7-dihydro-2H-thiazolo[3, 2-a]-pyrimidine-6-carboxylate derivatives (6a-j). Elemental analysis, IR, 1H NMR and mass spectral data el

Synthesis and in vitro microbiological evaluation of novel 4-aryl-5-isopropoxycarbonyl-6-methyl-3,4-dihydropyrimidinones

Seven 4-aryl-5-isopropoxycarbonyl-6-methyl-3,4-dihydropyrimidin-2(1H)-ones 4a-g and 4-phenyl-5-isopropoxycarbonyl-6-methyl-3,4-dihydropyrimidin-2(1H)-thione 4h have been synthesized by a one-pot cyclocondensation of aldehydes, isopropyl acetoacetate and u

Calcium fluoride: an efficient and reusable catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and their corresponding 2(1H)thione: an improved high yielding protocol for the Biginelli reaction

A simple and effective synthesis of 3,4-dihydropyrimidinone derivatives from aldehydes, 1,3-dicarbonyl compounds, and urea/thiourea in ethanol by using calcium fluoride as catalyst has been described. Compared with classical Biginelli reaction conditions,