321707-23-7

Upstream product

• 279246-01-4 tert-butyl ((4-bromophenyl)-sulfonyl)carbamate 
• 701-34-8 4-bromo-benzenesulfonic acid amide 
• 98-58-8 4-bromobenzenesulfonyl chloride 
• 2450-71-7 Propargylamine 

Downstream Products

• 1198357-09-3 C₁₈H₁₆Br₂N₂O₄S₂ 
• 1308685-15-5 C₂₃H₂₄BrNO₄S 
• 1308685-22-4 C₂₆H₂₈BrNO₄S 
• 1308685-26-8 C₂₉H₃₄BrNO₄S 
• 1308685-27-9 C₂₅H₂₈BrNO₄S 
• 1312368-71-0 C₁₈H₁₆BrNO₂S 
• 1426257-77-3 C₂₄H₂₅BrN₂O₄S 

Relevant academic research and scientific papers

Molecular diversity of trimethoxyphenyl-1,2,3-triazole hybrids as novel colchicine site tubulin polymerization inhibitors

Structurally diverse trimethoxyphenyl-1,2,3-triazole hybrids were designed, synthesized and evaluated for their antiproliferative activity against three cancer cell lines (PC3, MGC803 and HepG2). Among them, trimethoxyphenyl-1,2,3-triazole containing the

Ruthenium Carbene-Mediated Construction of Strained Allenes via the Enyne Cross-Metathesis/Cyclopropanation of 1,6-Enynes

Herein, we report on the unprecedented dimerization of 1,6-enynes using a commercially available ruthenium complex RuCl2(PPh3)3, which results in a series of bicyclo[3.1.0]hexyl allene derivatives in moderate to excellent yields. Mechanistic investigation indicates that the in-situ-generated ruthenium vinylidene undergoes a site-selective metathesis process to provide allenyl ruthenium carbene, which can be intramolecularly trapped by the pendent C=C bond of enyne through a [2 + 2] cycloaddition/metal elimination process.

Cu(I)-catalyzed oxidative cyclization of enynamides: Regioselective access to cyclopentadiene frameworks and 2-aminofurans

An efficient Cu(I)-catalyzed oxidative cyclization of alkynyl-tethered enynamides for the construction of fused bicyclic cyclopentadiene derivatives is disclosed. The cascade proceeds through alkyne oxidation, carbene/alkyne metathesis, and formal (3 + 2)

Structure optimization and bioactivity evaluation of ThDP analogs targeting cyanobacterial pyruvate dehydrogenase E1

Harmful cyanobacteria bloom (HCB) has occurred frequently in recent years and it is urgent to develop novel algicides to deal with this problem. In this paper, a series of novel thiamin diphosphate (ThDP) analogs 5a?5g were designed and synthesized target

Design, synthesis, biological evaluation and molecular docking of amide and sulfamide derivatives as Escherichia coli pyruvate dehydrogenase complex E1 inhibitors

In this study, a series of novel amide derivatives and sulfamide derivatives as potential E. coli PDHc E1 inhibitors were designed and synthesized by optimizing the linker between triazole and benzene ring moieties based on the structure of lead compound

Titanium(IV) chloride-mediated carbocyclization of 1,6-Enynes: Selective synthesis of 3-Azabicyclo[3.1.0]hexanes and functionalized allenes by controlling the reaction temperature

1,6-Enynes can be transformed into 3-azabicyclo[3.1.0]hexanes and functionalized allenes in moderate to good yields along with moderate to high diastereoselectivities by controlling the reaction temperature in the presence of titanium(IV) chloride. A plausible mechanism is proposed. 1,6-Enynes can be transformed into 3-azabicyclo[3.1.0]hexanes and functionalized allenes respectively in moderate to goodyields along with moderate to high diastereoselectivities by controlling the reaction temperature in the presence of titanium(IV) chloride. A plausible mechanism is proposed.

Synthesis of trisubstituted pyrroles from rhodium-catalyzed alkyne head-to-tail dimerization and subsequent goldcatalyzed cyclization

Dimerization of N-protected propargylic amines in a rather rare head-to-tail mode has been achieved under mild conditions with high selectivity using rhodium catalysts. The JV-protecting group could be a sulfonyl, carbamate, or carbonyl functionality and