321707-24-8

Upstream product

• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 2450-71-7 Propargylamine 

Downstream Products

• 1449846-51-8 (R)-2-(N-(2-(4-((4-fluorophenylsulfonamido)methyl)-1H-1,2,3-triazol-1-yl)ethyl)-4-methoxyphenylsulfonamido)-N-hydroxy-3-methylbutanamide 
• 1449846-59-6 (R)-2-(4-(2-fluoroethoxy)-N-(2-(4-((4-fluorophenylsulfonamido)methyl)-1H-1,2,3-triazol-1-yl)ethyl)phenylsulfonamido)-N-hydroxy-3-methylbutanamide 
• 1351556-91-6 4-fluoro-N-[1-(2-{2-[2-(2-{4-[2,4,6-trioxo-5-(4-phenoxyphenyl)hexahydropyrimidin-5-yl]piperazin-1-yl}ethoxy)ethoxy]ethoxy}ethyl)-1H-1,2,3-triazol-4-ylmethyl]benzenesulfonamide 
• 1268257-55-1 N-[-1-(2-{2-[2-(2-{5-[4-benzo[1,3]dioxol-5-yl-2-hydroxy-2-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-3-ylmethyl]-2,3-dimethoxyphenoxy}ethoxy)ethoxy]ethoxy}ethyl)-1H-1,2,3-triazol-4-ylmethyl]-4-fluorobenzenesulfonamide 

Relevant academic research and scientific papers

Discovery of a novel benzenesulfonamide analogue that inhibits proliferation and metastasis against ovarian cancer OVCAR-8 cells

Background: Ovarian cancer has been a salient public health concern in the world. It is necessary to develop novel antitumor drugs to treat ovarian cancer. Purpose: This study investigated the synthesis, antiproliferation ability, antitumor mechanisms in

Ruthenium Carbene-Mediated Construction of Strained Allenes via the Enyne Cross-Metathesis/Cyclopropanation of 1,6-Enynes

Herein, we report on the unprecedented dimerization of 1,6-enynes using a commercially available ruthenium complex RuCl2(PPh3)3, which results in a series of bicyclo[3.1.0]hexyl allene derivatives in moderate to excellent yields. Mechanistic investigation indicates that the in-situ-generated ruthenium vinylidene undergoes a site-selective metathesis process to provide allenyl ruthenium carbene, which can be intramolecularly trapped by the pendent C=C bond of enyne through a [2 + 2] cycloaddition/metal elimination process.

Structure optimization and bioactivity evaluation of ThDP analogs targeting cyanobacterial pyruvate dehydrogenase E1

Harmful cyanobacteria bloom (HCB) has occurred frequently in recent years and it is urgent to develop novel algicides to deal with this problem. In this paper, a series of novel thiamin diphosphate (ThDP) analogs 5a?5g were designed and synthesized target

Synthesis, in?vitro anticancer and antibacterial activities and in silico studies of new 4-substituted 1,2,3-triazole–coumarin hybrids

The 4-substituted 1,2,3-triazole core in designed coumarin hybrids (4–35) with diverse physicochemical properties was introduced by eco-friendly copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition under microwave irradiation. Coumarin–1,2,3-triazole–ben

Design, synthesis, biological evaluation and molecular docking of amide and sulfamide derivatives as Escherichia coli pyruvate dehydrogenase complex E1 inhibitors

In this study, a series of novel amide derivatives and sulfamide derivatives as potential E. coli PDHc E1 inhibitors were designed and synthesized by optimizing the linker between triazole and benzene ring moieties based on the structure of lead compound