321856-40-0Relevant articles and documents
Synthesis of Enantioenriched α,α-Difluoro-β-arylbutanoic Esters by Pd-Catalyzed Asymmetric Hydrogenation
Dong, Kaiwu,Feng, Sitian,Shen, Chaoren,Tang, Yitian,Yang, Chenjue
supporting information, p. 7508 - 7512 (2020/10/09)
Synthesis of optically active gem-difluorinated organic molecules attracts a great deal of interest due to their unique properties in pharmaceutical and agrochemical areas. Herein, a series of enantioenriched α,α-difluoro-β-arylbutanoic esters were prepar
Ligand-controlled regiodivergent palladium-catalyzed decarboxylative allylation reaction to access α,α-difluoroketones
Yang, Ming-Hsiu,Orsi, Douglas L.,Altman, Ryan A.
supporting information, p. 2361 - 2365 (2015/03/04)
α,α-Difluoroketones possess unique physicochemical properties that are useful for developing therapeutics and probes for chemical biology. To access the α-allyl-α,α-difluoroketone substructure, complementary palladium-catalyzed decarboxylative allylation reactions were developed to provide linear and branched α-allyl-α,α-difluoroketones. For these orthogonal processes, the fluorination pattern of the substrate enabled the ligands to dictate the regioselectivity of the transformations.
The Mitsunobu reaction in the synthesis of α,α-difluoro-β-amino acids
Fokina, Natalie A.,Kornilov, Andrei M.,Kukhar, Valery P.
, p. 69 - 76 (2007/10/03)
A three-stage strategy is proposed to prepare α,α-difluoro-β-amino acids starting from aldehydes and with ethyl bromodifluoroacetate as a fluorine source. The Mitsunobu reaction as a key step was studied by 31P and 19F NMR for alkyl-
