321921-83-9

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 100-39-0 benzyl bromide 
• 81028-03-7 (Z)-4-benzyloxy-but-2-en-1-ol 
• 122751-47-7 (Z)-4-phenylmethoxy-but-2-en-1-al 
• 69152-87-0 4-benzyloxycrotonaldehyde 

Downstream Products

• 251319-56-9 (2R,3R,4E)-2-methyl-3-(tert-butyldimethylsilyloxy)-6-(phenylmethoxy)hex-4-en-1-al 
• 321921-94-2 (2Z,4R,5R,6R,7R)-6-benzoyloxy-4-methyl-1,5-di-(tert-butyldimethylsiloxy)-7,8-di-(triphenylsiloxy)oct-2-ene 
• 321921-93-1 (2Z,4R,5R,6R,7R)-6-benzoyloxy-4-methyl-1,5-di-(tert-butyldimethylsiloxy)-7,8-di-(ttrimethylsiloxy)oct-2-ene 
• 321921-85-1 (2Z,4R,5R,6R)-6-benzoyloxy-4-methyl-1,5-di-(tert-butyldimethylsiloxy)-7,8-(isopropylidenedioxy)oct-2-ene 
• 251319-65-0 (2Z,6E)-(4S,5S)-8-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-4-methyl-octa-2,6-dienoic acid methyl ester 
• 251319-60-5 (2R,3S,4R,5R,6R,7R)-6-benzoyloxy-4-methyl-1,5-di-(tert-butyldimethylsiloxy)-7,8-di-(triethylsilyloxy)octa-2,3-oxirane 
• 251319-66-1 (2Z,4R,5R,6R,7R)-6-benzoyloxy-4-methyl-1,5-di-(tert-butyldimethylsiloxy)-7,8-di-(triethylsiloxy)oct-2-ene 
• 251319-59-2 (2R,3R,4R,5R,6Z)-3-benzoyloxy-5-methyl-4,8-di-(tert-butyldimethylsiloxy)-2,3-(oxirane) oct-6-en-1,2-diol 
• 321921-92-0 [(2E,6Z)-(4S,5S)-4,8-Bis-(tert-butyl-dimethyl-silanyloxy)-5-methyl-octa-2,6-dienyloxymethyl]-benzene 
• 321921-91-9 (2Z,6E)-(4S,5S)-8-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-4-methyl-octa-2,6-dien-1-ol 

Relevant academic research and scientific papers

Asymmetric epoxide cyclisation route to the F-pyran fragment of the altohyrtins and key aldol studies

The evolution of an asymmetric synthesis of a differentially protected F-pyran ring of the altohyrtins is described, which relies on a key intramolecular cyclisation of a C43 hydroxyl group onto a C38-C39 epoxide. The C38-C39 epoxide stereochemistry was achieved through optimisation of substrate control. Key aldol studies towards coupling the F-pyran ring with an E-pyran ring precursor was investigated, but unsuccessful. (C) 2000 Elsevier Science Ltd.