321980-83-0

Basic information

• Product Name: 2-(2-(4-bromobenzylidene)hydrazinyl)thiazol-4(5H)-one
• Synonyms: 2-(2-(4-bromobenzylidene)hydrazinyl)thiazol-4(5H)-one
• CAS NO: 321980-83-0
• Molecular Weight: 298.163
• Mol File: 321980-83-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-(4-bromobenzylidene)hydrazinyl)thiazol-4(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-(4-bromobenzylidene)hydrazinyl)thiazol-4(5H)-one(321980-83-0)
• EPA Substance Registry System: 2-(2-(4-bromobenzylidene)hydrazinyl)thiazol-4(5H)-one(321980-83-0)

Safety Data

• Hazardous Substances Data: 321980-83-0(Hazardous Substances Data)

Upstream product

• 36449-43-1 2-(4-bromobenzylidene)hydrazine carbothioamide 
• 105-36-2 ethyl bromoacetate 

Relevant articles and documents

Design, synthesis and biological evaluation of thiazolidinone derivatives as potential EGFR and HER-2 kinase inhibitors

Two series of thiazolidinone derivatives designing for potential EGFR and HER-2 kinase inhibitors have been discovered. Some of them exhibited significant EGFR and HER-2 inhibitory activity. Compound 2-(2-(5-bromo-2-hydroxybenzylidene)hydrazinyl)thiazol-4(5H)-one (12) displayed the most potent inhibitory activity (IC50 = 0.09 μM for EGFR and IC50 = 0.42 μM for HER-2), comparable to the positive control erlotinib. Docking simulation was performed to position compound 12 into the EGFR active site to determine the probable binding model. Antiproliferative assay results indicating that some of the thiazolidinone derivatives own high antiproliferative activity against MCF-7. Compound 12 with potent inhibitory activity in tumor growth inhibition would be a potential anticancer agent.