322-09-8

Basic information

• Product Name: Benzenepropanoic acid, a-fluoro-b-hydroxy-, ethyl ester
• CAS NO: 322-09-8
• Molecular Formula: C11H13FO3
• Molecular Weight: 212.221
• Mol File: 322-09-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, a-fluoro-b-hydroxy-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, a-fluoro-b-hydroxy-, ethyl ester(322-09-8)
• EPA Substance Registry System: Benzenepropanoic acid, a-fluoro-b-hydroxy-, ethyl ester(322-09-8)

Safety Data

• Hazardous Substances Data: 322-09-8(Hazardous Substances Data)

Upstream product

• 401-55-8 ethyl bromofluoroacetate 
• 100-52-7 benzaldehyde 
• 92397-82-5 ((E)-1-Ethoxy-2-fluoro-vinyloxy)-trimethyl-silane 
• 222724-37-0 ethyl 2-bromo-2-fluoro-3-hydroxy-3-phenylpropanoate 
• 83192-17-0 lithium enolate of ethyl fluoroacetate 
• 459-72-3 ethyl 2-fluoroacetate 

Downstream Products

• 1479-22-7 ethyl 2-fluoro-3-oxo-3-phenylpropionate 
• 2145-72-4 2-Fluor-3-hydroxy-3-phenyl-propionsaeurehydrazid 
• 2823-56-5 2-fluoro-3-hydroxy-3-phenyl-propionic acid 
• 20397-58-4 ethyl (E)-2-fluoro-3-phenylacrylate 
• 20397-59-5 ethyl (Z)-2-fluoro-3-phenylacrylate 

Relevant articles and documents

Preparation of α-Fluoro Enolates and Their Use in the Directed Aldol Reaction

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Stereoselective Reduction of α-Fluoro-β-keto Esters by NADH and NADPH-Dependent Ketoreductases

Racemic α-fluoro-β-keto esters were stereoselectively transformed to α-fluoro-β-hydroxy esters through dynamic reductive kinetic resolution (DYRKR) using commercially available NAD(P)H-dependent ketoreductases. Aromatic, alkenyl, and alkyl substrates were

Ethyl α-fluoro silyl enol ether: Stereoselective synthesis and its aldol reaction with aldehydes and ketones

Ethyl α-fluoro silyl enol ether is stereoselectively synthesized in high yield from inexpensive chlorofluoroacetate and Mg (or Zn) in DMF (or HMPA). Lewis acid promoted aldol reaction of this enol ether with aldehydes and ketones gives α-fluoro-β-hydroxy