32212-73-0

Basic information

• Product Name: 5α,6β-DibroMostigMastan-3β-yl 3-Acetate
• Synonyms: 5α,6β-DibroMostigMastan-3β-yl 3-Acetate
• CAS NO: 32212-73-0
• Molecular Formula: C₃₁H₅₀Br₂O₂
• Molecular Weight: 614.5355
• Product Categories: Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 32212-73-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 564.6±40.0 °C(Predicted)
• Appearance: /
• Density: 1.25±0.1 g/cm3(Predicted)
• Solubility: Chloroform, Dichloromethane
• CAS DataBase Reference: 5α,6β-DibroMostigMastan-3β-yl 3-Acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 5α,6β-DibroMostigMastan-3β-yl 3-Acetate(32212-73-0)
• EPA Substance Registry System: 5α,6β-DibroMostigMastan-3β-yl 3-Acetate(32212-73-0)

Safety Data

• Hazardous Substances Data: 32212-73-0(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

5α,6β-Dibromostigmastan-3β-yl 3-Acetate is a reactant used in the preparation of methylenecholestendiol and phytosterol biosynthesis.

Upstream product

• 83-48-7 Stigmasterol 
• 67-66-3 chloroform 
• 4651-48-3 acetic acid stigmasteryl ester 
• 7726-95-6 bromine 
• 4651-48-3 stigmasterol acetate 

Downstream Products

• 53-43-0 dehydroepiandrosterone 
• 145-13-1 Pregnenolone 
• 53906-49-3 3β-ol-23,24-bisnor-chol-5-en-22-al hemihydrochloride 
• 58526-32-2 3β-acetoxy-20(S)-5α-bisnorcholanic acid 
• 1474-14-2 3β-acetoxybisnor-5-cholenic acid 
• 10211-88-8 (20S)-3β-acetoxybisnorchol-5-en-22-al 

Relevant articles and documents

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NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF

Provided are methods of evaluating or treating a patient, e.g., a patient having a disorder described herein, comprising: a) optionally, acquiring a patient sample; b) acquiring an evaluation of and/or evaluating the sample for an alteration in the level S24(S)-hydroxycholesterol compared to a reference standard.

Synthesis of polyhydroxysterols (I): Synthesis of 24-methylenecholest-4-en-3β,6β-diol, a cytotoxic natural hydroxylated sterol

Starting from stigmasterol (2), 24-methylenecholest-4-en-3β,6β-diol (1), a cytotoxic natural dihydroxylated sterol, was synthesized via 10 steps in 20% overall yield. The introduction of a side-chain of sterol was achieved by solid-liquid phase-transfer Wittig reaction using (3-methyl-2-oxo)butyltriphenylarsonium bromide (12) and K2CO3. Construction of the steroidal nucleus was finished by the addition of 3β-acetoxycholest-5,6-en-24-one (7) with NBA in dioxane under ambient temperature and by the elimination of 3β, 6β-diacetoxy-5a-bromocholestane-24-one (9). The spectral data of the synthetic product (1) are completely consistent with those of the natural compound (1). Copyright (C) 2001 Elsevier Science Inc.