32262-18-3

Usage

Uses

Used in Pharmaceutical Industry:
4-METHOXY-1-METHYL-2(1H)-QUINOLINONE is used as an antimalarial agent for its potential to combat malaria, a disease caused by Plasmodium parasites.
4-METHOXY-1-METHYL-2(1H)-QUINOLINONE is also used as an anticancer agent for its ability to inhibit the growth of cancer cells, offering a possible treatment for various types of cancer.
Used in Chemical Synthesis:
In the chemical industry, 4-METHOXY-1-METHYL-2(1H)-QUINOLINONE is used as a building block in organic synthesis, contributing to the creation of new pharmaceutical compounds and other chemical products.
Used in Research and Development:
4-METHOXY-1-METHYL-2(1H)-QUINOLINONE serves as a subject of research for further exploration of its properties and potential applications, particularly in the development of new drugs and therapies.

InChI:InChI=1/C11H11NO2/c1-12-9-6-4-3-5-8(9)10(14-2)7-11(12)13/h3-7H,1-2H3

Upstream product

• 186581-53-3 diazomethane 
• 70254-44-3 2,4-dihydroxyquinoline 
• 61469-95-2 1-methyl-1H-quinoline-2,4-dione 
• 77-78-1 dimethyl sulfate 
• 27667-34-1 4-methoxy-2-hydroxyquinoline 
• 74-88-4 methyl iodide 
• 1677-46-9 4-hydroxy-1-methyl-2(1H)-quinolone 
• 70254-43-2 4-Hydroxy-2-quinolone 
• 27667-34-1 4-methoxyquinolin-2(1H)-one 
• 124-41-4 sodium methylate 
• 39581-30-1 3-(N-methyl-N-phenylamino)-3-oxopropanenitrile 
• 60657-74-1 3-(methyl(phenyl)amino)-3-oxopropanoic acid 
• 42014-51-7 bromoacetic acid N-hydroxusuccinimidyl ester 
• 85-91-6 Methyl N-methylanthranilate 

Downstream Products

• 61469-95-2 1-methyl-1H-quinoline-2,4-dione 
• 13849-56-4 Edulinin 

Relevant academic research and scientific papers

An organocatalyst bound α-aminoalkyl radical intermediate for controlled aerobic oxidation of iminium ions

A catalyst bound α-aminoalkyl radical intermediate from iminium is developed to control its formation and reactivity with aerobic oxygen. The influence of the catalyst was demonstrated via the ease of radical intermediate formation and its subsequent reactivity, including the first catalyst-controlled enantioselective aerobic oxidation with a chiral phosphite catalyst.

Synthesis of 3,4-disubstituted quinolin-2-(1H)-ones via palladium-catalyzed decarboxylative arylation reactions

The Pd-catalyzed decarboxylative cross-coupling reaction of 4-substituted quinolin-2(1H)-one-3-carboxylic acids with (hetero)aryl halides is described. With palladium(II) bromide and triphenylarsine ligand as the catalyst system, a variety of 4-substituted 3-(hetero)aryl quinolin-2(1 H)-ones and related heterocycles, such as 4-substituted 3-arylcoumarins can be prepared in good to excellent yields. Copyright

Resin-bound (succinimid-1-yloxycarbonylmethyl)triphenylphosphonium ylide - A synthon for rapid access to diverse heterocycles under microwave heating

The synthesis of a novel and versatile resin-bound (succinimid-1- yloxycarbonylmethyl)triphenylphosphonium ylide is described. The use of this resin to the synthesis of several diverse heterocycles, whilst allowing for ease of workup, is reported. Georg Thieme Verlag Stuttgart.

BACTERIOSTATIC HETEROCYCLES FROM EUODIA LUNU-ANKENDA

A new constituent characterized as 8-acetyl-3,4-dihydroxy-5,7-dimethoxy-2,2-dimethylchroman has been isolated together with alloevodionol-7-methyl ether, 4-methoxy-1-methyl-2(1H) quinolinone, evolitrine, isoevodionol and its methyl ether from the aerial parts of Euodia lunu-ankenda.Its structure was confirmed by its transformation to alloevodionol-7-methyl ether. 4-Methoxy-1-methyl-2(1H)quinolinone and its isomer were synthesized by a modified procedure.Key Word Index - Euodia lunu-ankenda; Rutaceae; 8-acetyl-3,4-dihydroxy-5,7-dimethoxy-2,2-dimethylchroman; alloevodionol-7-methyl ether; 4-methoxy-1-methyl-2(1H)quinolinone; isoevodionol; isoevodionol methyl ether; antibacterial activity.

Pharmaceutical preparation and use of 4-hydroxy-2-quinolinone-3-carboxylic acid esters

Disclosed are compounds which are 4-hydroxy-2-quinolinone-3-carboxylic acid esters, e.g., 1-methyl-4-hydroxy-2-quinolinone-3-carboxylic acid ethyl ester, useful as anti-allergic agents and intermediates for 1-alkyl-4-alkoxy-quinolin-2(1H)-ones, and prepared by reacting an isatoic anhydride with an alkali metal salt of a malonic ester.

Methylation of 4-Hydroxy-2-quinolone

The reaction of 4-hydroxy-2-quinolone (1a) with methyl iodide/potassium hydroxide in boiling acetone gave a mixture of 1-methyl-4-methoxy-2-quinolone (1d), 1,3-dimethyl-4-methoxy-2-quinolone (1e), and 1,3,3-trimethyl-2,4-dioxo-1,2,3,4-tetrahydroquinoline (2).As by-product 2,4-dimethoxyquinoline (3) was identified.Under the same conditions 4-methoxy-2-quinolone (1c) yielded 1d, 1e, 2 and 3, while 1-methyl-4-hydroxy-2-quinolone (1b) gave 1d, 1e and 2.