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27667-34-1

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27667-34-1 Usage

Description

4-Methoxy-1H-quinolin-2-one, also known as 4-Methoxy-1H-quinolin-2(1H)-one or 4-Methoxyquinolin-2(1H)-one, is an organic compound belonging to the class of quinolone molecules. It is a quinolone alkaloid with a methoxy group attached to the quinoline ring, characterized by the chemical formula C10H9NO2 and a molecular weight of 175.18 g/mol. 4-Methoxy-1H-quinolin-2-one is commonly found in natural sources such as plants and microorganisms and has demonstrated potential for various biological activities, including antiviral, antibacterial, and antifungal properties. Furthermore, 4-Methoxy-1H-quinolin-2-one has been studied for its potential use in pharmaceutical and medicinal applications.

Uses

Used in Pharmaceutical Industry:
4-Methoxy-1H-quinolin-2-one is used as a pharmaceutical intermediate for the development of new drugs due to its diverse biological activities, including antiviral, antibacterial, and antifungal properties. Its presence in natural sources and potential for medicinal applications make it a promising candidate for the synthesis of novel therapeutic agents.
Used in Antiviral Applications:
4-Methoxy-1H-quinolin-2-one is used as an antiviral agent for the treatment of various viral infections. Its antiviral properties make it a valuable compound in the development of new antiviral drugs to combat viral diseases.
Used in Antibacterial Applications:
4-Methoxy-1H-quinolin-2-one is used as an antibacterial agent for the treatment of bacterial infections. Its antibacterial properties contribute to the development of new antibiotics to address the growing issue of antibiotic resistance.
Used in Antifungal Applications:
4-Methoxy-1H-quinolin-2-one is used as an antifungal agent for the treatment of fungal infections. Its antifungal properties make it a valuable compound in the development of new antifungal drugs to combat fungal diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 27667-34-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,6,6 and 7 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 27667-34:
(7*2)+(6*7)+(5*6)+(4*6)+(3*7)+(2*3)+(1*4)=141
141 % 10 = 1
So 27667-34-1 is a valid CAS Registry Number.
InChI:InChI=1/C10H9NO2/c1-13-9-6-10(12)11-8-5-3-2-4-7(8)9/h2-6H,1H3,(H,11,12)

27667-34-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Methoxy-1H-quinolin-2-one

1.2 Other means of identification

Product number -
Other names 4-methoxyquinolin-2(1H)-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
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More Details:27667-34-1 SDS

27667-34-1Relevant articles and documents

Synthesis and characterization of substituted 4-methoxy-1H-quinolin-2- thiones

Ramasamy,Balasubramaniam,Mohan

, p. 4726 - 4728 (2012/09/07)

The synthesis of various substituted 4-methoxy-1H-quinolin-2-thiones from various substituted aniline with malonic acid, phosphorousoxychloride, sodium methoxide glacial acetic acid and thiourea under different conditions is described. All these substituted 4-methoxy-1H-quinolin-2-thiones were synthesized from four steps; the first step involved the synthesis of substituted 2,4-dichloro quinoline from aniline (substituted), with malonic acid and phosphorous-oxychloride. In the second step, the substituted 2,4-dichloro compound was heated with freshly prepared methanolic sodium methoxide solution to give 2,4-dimethoxy quinoline compounds, it was then refluxed with glacial acetic acid and hydrochloric acid to get the substituted 4-methoxy-1H-quinolin- 2-one. The final steps involves with an objective of introducing a chloro in the position 2 of the quinolone system, the substituted 4-methoxy-1H-quinolin-2-one was refluxed with distilled PoCl3 chloroform. The substituted 2-chloro-4-methoxy quinoline was then refluxed with thiourea and alcohol to get substituted 4-methoxy-1H-quinolin-2-thiones. The purity of the synthesized compound was judged by their C, H and N analysis and the structure was analyzed on the basics of mass, FT-IR and 1H NMR.

Synthesis of (+)-myrtopsine, (+)-7,8-dimethoxymyrtopsine, and related 2,3-dihydro-3-hydroxy-2-(1-hydroxy-1-methyl-ethyl)benzofuran natural products

Snider, Barry B.,Wu, Xiaoxing

, p. 279 - 294 (2008/04/18)

The first syntheses of myrtopsine (8t) and 7,8-dimethoxymyrtopsine (9t) have been carried out by halogen-metal exchange of 3-iodo-4-methoxy-quinolin-2(1H)-ones (15) and (21) with i-PrMgCl followed by addition of 3,3-dimethyloxirane-2-carboxaldehyde (1). A two-step sequence leads selectively to trans-2,3-dihydro-3-hydroxy-2-(1-hydroxy-1-methylethyl)benzofurans (7t), (8t), (9t), (28), and (32) by conversion of a 2-iodophenol or a 3-iodo-4-methoxyquinolin-2(1H)-one to an aryl Grignard reagent and addition of 3-methyl-2-butenal, followed by threo selective epoxidation of the resulting allylic alcohol and cyclization with inversion.

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