32272-23-4

Upstream product

• 1314539-19-9 2'-hydroxyl-4'-methoxy-4-methoxymethoxychalcone 
• 6515-21-5 4-methoxymethoxy-benzaldehyde 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 21785-09-1 7-methoxyflavanone 
• 145370-40-7 7-methoxy-4'-nitroflavone 
• 131944-42-8 7-hydroxy-2-(4'-nitrophenyl)chromone 
• 66715-17-1 2-(4-benzyloxy-phenyl)-7-methoxy-chromen-4-one 
• 921942-36-1 2-(4-amino-phenyl)-7-methoxy-chromen-4-one 
• 2196-14-7 7,4'-Dihydroxyflavon 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 32272-24-5 2-(4-acetoxy-phenyl)-7-methoxy-chromen-4-one 
• 20979-50-4 4,7-dimethoxyflavone 
• 112864-32-1 7-methoxy-2-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-chromen-4-one 

Relevant academic research and scientific papers

Scope and Applications of 2,3-Oxidative Aryl Rearrangements for the Synthesis of Isoflavone Natural Products

The reaction of flavanones with hypervalent iodine reagents was investigated with a view to the synthesis of naturally occurring isoflavones. In contrast to several previous reports in the literature, we did not observe the formation of any benzofurans via a ring contraction pathway, but could isolate only isoflavones, resulting from an oxidative 2,3-aryl rearrangement, and flavones, resulting from an oxidation of the flavanones. Although the 2,3-oxidative rearrangement allows a synthetically useful approach toward some isoflavone natural products due to the convenient accessibility of the required starting materials, the overall synthetic utility and generality of the reaction appear to be more limited than previous literature reports suggest.

Microbial Transformations of 7-Methoxyflavanone

Microbial transformations of racemic 7-methoxyflavanone using strains of the genus Aspergillus (A. niger KB, A. ochraceus 456) and the strain Penicillium chermesinum 113 were described. The strain A. niger KB catalysed carbonyl group reduction, leading to (±)-2,4-cis-7-methoxyflavan-4-ol. Biotransformation with the help of A. ochraceus 456 gave two products: (+)-2,4-trans-7-methoxyflavan-4-ol and 4'-hydroxy-7-methoxyflavone. Transformation by means of P. chermesinum 113 resulted in a dihydrochalcone product, 4,2'-dihydroxy-4'-methoxydihydrochalcone. DPPH scavenging activity test proved that all the biotransformations products have higher antioxidant activity that the substrate.