145370-40-7

Upstream product

• 131944-42-8 7-hydroxy-2-(4'-nitrophenyl)chromone 
• 77-78-1 dimethyl sulfate 
• 122-04-3 4-nitro-benzoyl chloride 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 462610-98-6 1-(2-((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)ethan-1-one 
• 62-23-7 4-nitro-benzoic acid 
• 36695-18-8 4'-methoxy-2'-(4-nitrobenzoyloxy)acetophenone 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 111599-77-0 2'-hydroxy-4'-methoxyphenyl-4-nitrostyrylketone 
• 462611-21-8 1-[2-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-3-(4-nitro-phenyl)-propane-1,3-dione 

Downstream Products

• 921942-36-1 2-(4-amino-phenyl)-7-methoxy-chromen-4-one 
• 1371663-62-5 4-(2-hydroxy-4-methoxyphenyl)-6-(4-nitrophenyl)-2-aminopyrimidine 
• 32272-24-5 2-(4-acetoxy-phenyl)-7-methoxy-chromen-4-one 
• 20979-50-4 4,7-dimethoxyflavone 
• 32272-23-4 2-(4-hydroxyphenyl)-7-methoxychromen-4-one 

Relevant academic research and scientific papers

Assessment of antiplatelet activity of 2-aminopyrimidines

A series of 4,6-diaryl-2-aminopyrimidines was developed as antiplatelet agents and their potency was evaluated by in vitro assay. Compound 14k was found to be two times more potent than aspirin. These encouraging results could be helpful for the development of new antiplatelet compounds.

Synthesis and preliminary biological evaluation of chrysin derivatives as potential anticancer drugs

A series of chrysin derivatives were prepared from 2-hydroxyacetophenone, 2,4-dihydroxyacetophenone, 2,4,6-trihydroxy- acetophenone, using modified Baker-Venkataraman transformation. Their anticancer activities in vitro were evaluated by the standard MTT method. The results of biological test showed that some of chrysin derivatives showed stronger anticancer activity than 5-fluorouracil.

Efficient synthesis of nitroflavones by cyclodehydrogenation of 2prime;-hydroxychalcones and by the Baker-Venkataraman method

Several nitroflavone derivatives were synthesized by cyclodehydrogenation of 2′-hydroxychalcones and by the Baker-Venkataraman approach, starting from 2′-hydroxyacetophenones and benzoic acid derivatives. Nitroflavones synthesised by the first synthetic a

Synthesis and biological evaluation of some novel 4H-benzopyran-4-one derivatives as nonsteroidal antiestrogens

The preparation and characterization of some novel 2- and 3-substituted-7-methoxy-4H-1-benzopyran-4-one are presented. The synthesized compounds were evaluated for their uterotrophic, antiuterotrophic and antiimplantation activities in mature female albino rats. 3-Benzyl-7-methoxy-4H-1-benzopyran-4-one (14) showed the highest uterotrophic activity (87%) based on dry uterine weight gain. The antifertility activity, as assessed by the post-coital antiimplantation activity test, was of weak potency for most compounds (14-29%). Among the products, the 2-(4′-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one (19) exhibited the highest antiestrogenic activity of 65%. It also elicited 31% of the uterotrophic activity of estradiol.