32276-18-9Relevant academic research and scientific papers
Biofilm inhibition and anti-Candida activity of a cationic lipo-benzamide molecule with twin-nonyl chain
Jain, Tushar,Muktapuram, Prathap Reddy,Sharma, Komal,Ravi, Owk,Pant, Garima,Mitra, Kalyan,Bathula, Surendar Reddy,Banerjee, Dibyendu
supporting information, p. 1776 - 1780 (2018/04/23)
A series of cationic lipo-benzamide compounds with varying lengths of hydrocarbon chains (C2M–C18M) were evaluated for anti-Candida activity. Four compounds harbouring 8–11 hydrocarbon chains demonstrated concentration-dependent inhibition of fungal cell
Direct amide synthesis from equimolar amounts of carboxylic acid and amine catalyzed by mesoporous silica SBA-15
Tamura, Mizuki,Murase, Daisuke,Komura, Kenichi
supporting information, p. 769 - 776 (2015/03/14)
Direct amide synthesis from equimolar amounts of carboxylic acid and amine using mesoporous silica as a versatile heterogeneous catalyst is reported.
Anticancer siRNA delivery by new anticancer molecule: A novel combination strategy for cancer cell killing
Muktapuram, Prathap Reddy,Gara, Rishi Kumar,Sharma, Komal,Rohit, Chilappa,Srinivas, Kolupula,Mishra, Durga Prasad,Bathula, Surendar Reddy
, p. 400 - 408 (2013/01/15)
The present report describes development of a novel, bifunctional molecule possessing both selective antiproliferative activity and siRNA transfection ability. We synthesized a series of cationic lipo-benzamides and screened for in vitro anticancer activities against a panel of cancer and non-cancer cells. The molecule with a ten carbon chain-length (C10M) significantly inhibited proliferation of cancer cells via arresting the cell cycle predominantly in the G1 phase; but did not affect non-cancerous cells. C10M effectively mediated siRNA delivery in vitro. The combined anticancer effect of the delivery of C10M together with its survivin-targeting siRNA cargo was significantly (p a dual-purpose molecule with intrinsic anticancer activity and suitability for use in siRNA delivery.
