32338-15-1Relevant academic research and scientific papers
Microwave-assisted catalytic amination of phenothiazine; Reliable access to phenothiazine analogues of Troeger's base
Gaina, Luiza I.,Mataranga-Popa, Larisa N.,Gal, Emese,Boar, Paul,Loennecke, Peter,Hey-Hawkins, Evamarie,Bischin, Cristina,Silaghi-Dumitrescu, Radu,Lupan, Iulia,Cristea, Castelia,Silaghi-Dumitrescu, Luminita
, p. 5500 - 5508 (2013)
Efficient protocols for microwave-assisted catalyzed amination of halogeno-phenothiazines are described. Phenothiazine analogues of Troeger's base (PTB) were obtained by condensation of amino-phenothiazines with formaldehyde in HCl/EtOH/H2O and
Human moricizine metabolism. I. Isolation and identification of metabolites in human urine
Richards,Pieniaszek Jr.,Shatzmiller,Page,Blom,Read,Davidson,Confalone
, p. 217 - 229 (2007/10/03)
1. Using synthetic standards and/or spectral data, seven moricizine metabolites were structurally identified in human urine. Two novel metabolites were identified as phenothiazine-2-carbamic acid and ethyl [10-(3-aminopropionyl) phenothiazin-2-yl] carbamate. Two novel human moricizine metabolites, 2-amino-10-(3-morpholinopropionyl) phenothiazine, a previously identified dog metabolite, and 2-aminophenothiazine, a previously identified rat metabolite, were also identified. Three additional human metabolites, phenothiazine-2-carbamic acid ethyl ester sulphoxide (P2CAEES), moricizine sulphoxide, and ethyl {10-[N-(2'-hydroxyethyl)3-aminopropionyl] phenothiazin-2-yl} carbamate, all previously described in the literature, were observed. 2. Both 2-amino-10-(3-morpholinopropionyl) phenothiazine and ethyl [10-(3-aminopropionyl) phenothiazin-2-yl] carbamate, and possibly ethyl {10-[N-(2'-hydroxyethyl)3-aminopropionyl]phenothiazin-2-yl} carbamate, possess the structural characteristics thought to be necessary for class 1 antiarrhythmic activity.
