32346-07-9

Basic information

• Product Name: Silane, [(1-methoxy-2-phenylethenyl)oxy]trimethyl-, (Z)-
• CAS NO: 32346-07-9
• Molecular Formula: C12H18O2Si
• Molecular Weight: 222.359
• Mol File: 32346-07-9.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Silane, [(1-methoxy-2-phenylethenyl)oxy]trimethyl-, (Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, [(1-methoxy-2-phenylethenyl)oxy]trimethyl-, (Z)-(32346-07-9)
• EPA Substance Registry System: Silane, [(1-methoxy-2-phenylethenyl)oxy]trimethyl-, (Z)-(32346-07-9)

Safety Data

• Hazardous Substances Data: 32346-07-9(Hazardous Substances Data)

Upstream product

• 27607-77-8 trimethylsilyl trifluoromethanesulfonate 
• 101-41-7 benzeneacetic acid methyl ester 
• 40195-27-5 (1-methoxy-2-phenylvinyloxy)trimethylsilane 
• 75-77-4 chloro-trimethyl-silane 

Downstream Products

• 14815-73-7 methyl allylphenylacetate 
• 88517-43-5 3-Benzyloxyamino-2-phenyl-propionic acid methyl ester 
• 94143-86-9 3-(1,1,1,3,3,3-Hexamethyl-disilazan-2-yl)-2-phenyl-propionic acid methyl ester 
• 1025769-75-8 methyl 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,3-diphenylpropanoate 
• 59845-64-6 3,3-dimethoxy-2-phenyl-propionic acid methyl ester 
• 99092-02-1 methyl 3-amino-2-phenylpropanoate 
• 113-45-1 methyl (R*)-2-phenyl-2-((S*)-piperidin-2-yl)acetate 
• 113-45-1 dl-threo-methylphenidate 
• 112084-92-1 Phenyl-(2-phenyl-[1,3]dioxolan-2-yl)-acetic acid methyl ester 
• 17147-72-7 [1,3]Dioxolan-2-yl-phenyl-acetic acid methyl ester 
• 112084-91-0 (2-Methyl-[1,3]dioxolan-2-yl)-phenyl-acetic acid methyl ester 

Relevant articles and documents

Asymmetric syntheses of nakinadine D, nakinadine E, and nakinadine F: Confirmation of their relative (RS, SR)-configurations and proposal of their absolute (2 S,3 R)-configurations

The syn- and anti-diastereoisomeric forms of the reported structures of the marine alkaloids nakinadines D-F have been synthesized, for the first time in all cases, via an approach involving asymmetric Mannich-type (imino-aldol) reactions of methyl phenylacetate with N-tert-butylsulfinyl imines as the key steps to control the stereochemistry. Comparison of the 1H and 13C NMR spectroscopic data reported for the natural materials with those acquired for these synthetic samples confirms the initially assigned relative (RS,SR)-configurations of these three alkaloids. In the absence of specific rotation (or other diagnostic) data for the natural materials, it is not possible to unambiguously assign their absolute configurations, although given the absolute (2S)-configurations assigned to nakinadines B and C, and the absolute (2S,3R)-configuration previously established for nakinadine A, the data herein uphold our proposal that nakinadines D-F share the absolute (2S,3R)-configuration.

Copper-catalyzed amination of silyl ketene acetals with N-chloroamines

A copper(I)/2,2′-bipyridyl complex catalyzes an amination reaction of silyl ketene acetals with N-chloroamines, presenting a new preparative method of α-amino esters.

MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-κB ACTIVITY AND USE THEREOF

Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including inflammatory and immune diseases, obesity and diabetes having the structure of formula (I), its enantiomers, diastereomers, or a pharmaceutically acceptable salt, or hydrate, thereof, wherein X is (Ia); or X is (Ib); or X is (Ic); (Id) is heterocycle or heteroaryl; E is -N-, -NR1-, -O-, -S-, -SO2- or -CR2-; F is -N-, -NR1a-, -O-, -S-, SO2- or -CR2a-; G is N, -NR1b-, -O-, -S-, SO2- or -CR2b-, provided that the E-F-G containing heterocyclic ring formed does not contain a S-S or S-O bond, and at least one of E, F and G is a heteroatom; J, Ja, M, Ma, Q, Rx, Ry, R1, R1a, R1b, R2, R2a, R2b, and R3 to R21, Z, Za, Zb, and Zc are as defined above.