94143-86-9Relevant academic research and scientific papers
N,N-Bis(trimethylsilyl)methoxymethylamine as a Convenient Synthetic Equivalent for +CH2NH2: Primary Aminomethylation of Esters
Okano, Kohji,Morimoto, Toshiaki,Sekiya, Minoru
, p. 883 - 884 (1984)
The introduction of a primary aminomethyl unit at the α position of esters can be achieved in high yield by the silyl trifluoromethanesulphonate-catalysed reaction of ketene silyl acetals (2) with N,N-bis(trimethylsilyl)methoxymethylamine (1).
Primary Aminomethylation at the α-Position of Carboxylic Acids and Esters. Trimethylsilyl Triflate-Catalyzed Reaction of Ketene Silyl Acetals with N,N-Bis(trimethylsilyl)methoxymethylamine
Okano, Kohji,Morimoto, Toshiaki,Sekiya, Minoru
, p. 2228 - 2234 (2007/10/02)
A new, general method for the synthesis of β-aminocarboxylic esters (9) and acids (10) was developed.The introduction of primary aminomethyl unit at the α-position of carboxylic esters (2) and acids (3) was achieved in high yields by the silyl trifluorome
