32363-47-6Relevant academic research and scientific papers
Iodine Promoted Conversion of Esters to Nitriles and Ketones under Metal-Free Conditions
Xiao, Jing,Guo, Fengzhe,Li, Yinfeng,Li, Fangshao,Li, Qiang,Tang, Zi-Long
, p. 2028 - 2035 (2021/02/03)
We report a novel strategy to prepare valuable nitriles and ketones through the conversion of esters under metal-free conditions. By using the I2/PCl3 system, various substrates including aliphatic and aromatic esters could react with acetonitrile and arenes to afford the desired products in good to excellent yields. This method is compatible with a number of functional groups and provides a simple and practical approach for the synthesis of nitrile compounds and aryl ketones.
The "kinetic capture" of an acylium ion from live aluminum chloride promoted Friedel-Crafts acylation reactions
Huang, Zhiliang,Jin, Liqun,Han, Heyou,Lei, Aiwen
supporting information, p. 1810 - 1814 (2013/04/10)
AlCl3 promoted Friedel-Crafts acylation between 4-tert-butylbenzoyl chloride and mesitylene was investigated. The donor-acceptor complex was observed as the major species. Kinetic investigation demonstrated that the reaction was first-order on the donor-acceptor complex and zero-order on ArH, suggesting that the donor-acceptor complex was not the true reactive species. However, the acylium ion was almost invisible with a fairly low concentration under live reaction conditions. It was approved as the true reactive species through kinetic data ("kinetic capture") in the AlCl3 promoted Friedel-Crafts acylation reaction.
Ring tert-butylation of benzophenones and benzaldehyde with tert-butyllithium and thionyl chloride
Olah,Wu,Farooq
, p. 1179 - 1182 (2007/10/02)
One-flask ring tert-butylation of benzophenones and benzaldehyde with tert-butyllithium and thionyl chloride is reported. The scope of the reaction and the suggested mechanism are discussed.
NEW METHODOLOGY IN DETERMINING EVIDENCE FOR SINGLE ELECTRON TRANSFER IN THE REACTION OF GRIGNARD REAGENTS WITH KETONES
Zhang, Yunshi,Wenderoth, Bernd,Su, Wei-Yang,Ashby, E. C.
, p. 29 - 38 (2007/10/02)
A new method is reported to determine the existence of single electron transfer in the reaction of Grignard reagents with ketones.The method involves the determination of pseudo-first order rate constants by following the rate of disappearance of the paramagnetic intermediate and relating the rate of this disappearance to the appearance of the product.The reactions of methyl-, phenyl- and t-butyl-Grignard reagents with substituted benzophenones were examined.This method should be applicable to a wide range of organometallic reactions.
