1150-51-2

Basic information

• Product Name: Methanone, (4-methoxyphenyl)(2,4,6-trimethylphenyl)-
• CAS NO: 1150-51-2
• Molecular Formula: C17H18O2
• Molecular Weight: 254.329
• Mol File: 1150-51-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Methanone, (4-methoxyphenyl)(2,4,6-trimethylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (4-methoxyphenyl)(2,4,6-trimethylphenyl)-(1150-51-2)
• EPA Substance Registry System: Methanone, (4-methoxyphenyl)(2,4,6-trimethylphenyl)-(1150-51-2)

Safety Data

• Hazardous Substances Data: 1150-51-2(Hazardous Substances Data)

Upstream product

• 100-07-2 4-methoxy-benzoyl chloride 
• 108-67-8 1,3,5-trimethyl-benzene 
• 77775-86-1 4-Methoxybenzoesaeure-difluorophosphorsaeure-anhydrid 
• 402-52-8 methyl 4-(trifluoromethyl)phenyl ether 
• 121-98-2 methyl 4-methoxybenzoate 
• 938-18-1 mesitylene-2-carboxylic acid chloride 
• 5720-07-0 4-methoxyphenylboronic acid 
• 5980-97-2 mesitylboronic acid 
• 100-66-3 methoxybenzene 
• 86487-17-4 2-tri-n-butylstannylanisole 
• 794-94-5 p-Methoxybenzoic anhydride 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 1146-83-4 4-Bromo-2',4',6'-trimethylbenzophenone 
• 917-58-8 potassium ethoxide 

Downstream Products

• 1150-52-3 2.4.6-Trimethyl-4'-methoxy-thiobenzophenon 
• 32363-47-6 (4-(tert-butyl)phenyl)(mesityl)methanone 

Relevant articles and documents

Iodine Promoted Conversion of Esters to Nitriles and Ketones under Metal-Free Conditions

We report a novel strategy to prepare valuable nitriles and ketones through the conversion of esters under metal-free conditions. By using the I2/PCl3 system, various substrates including aliphatic and aromatic esters could react with acetonitrile and arenes to afford the desired products in good to excellent yields. This method is compatible with a number of functional groups and provides a simple and practical approach for the synthesis of nitrile compounds and aryl ketones.

Sterically Hindered Ketones via Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling of Amides by N-C(O) Activation

Herein, we report a new protocol for the synthesis of sterically hindered ketones that proceeds via palladium-catalyzed Suzuki-Miyaura cross-coupling of unconventional amide electrophiles by selective N-C(O) activation. Mechanistic studies demonstrate that steric bulk on the amide has a major impact, which is opposite to the traditional Suzuki-Miyaura cross-coupling of sterically hindered aryl halides. Structural and computational studies provide insight into ground-state distortion of sterically hindered amides and show that ortho-substitution alleviates the N-C(O) bond twist.

Selective synthetic routes to sterically hindered unsymmetrical diaryl ketones via arylstannanes

Bulky arylstannanes and bulky aroyl chlorides are good reaction partners for the synthesis of two-, three-, and even four-ortho-substituted benzophenones, in good to excellent isolated yields (47-91%). Three simple and direct routes, with differential advantages, are proposed: (i) a catalyst-free protocol, in o-dichlorobenzene (ODCB) at 180 °C; (ii) a room temperature protocol, using AlCl3 (0.5 equiv), in dichloromethane (DCM); and (iii) a solvent-free, indium-promoted procedure. A radical mechanism is proposed for the indium-mediated reactions.2011 American Chemical Society.