32372-83-1Relevant articles and documents
COMPOUNDS INHIBITING TDG ACTIVITY
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, (2022/04/03)
The present invention provides a class of compounds inhibiting TDG activity. Specifically, the present invention provides a compound having a novel structure as shown in formula I. The small molecule inhibitor of the present invention has an excellent inhibitory effect on TDG.
Isoindolinone Synthesis: Selective Dioxane-Mediated Aerobic Oxidation of Isoindolines
Thapa, Pawan,Corral, Esai,Sardar, Sinjinee,Pierce, Brad S.,Foss, Frank W.
, p. 1025 - 1034 (2019/01/24)
N-Alkyl and N-aryl-isoindolinones were prepared by a dioxane-mediated oxidation of isoindoline precursors. The transformation exhibits unique chemoselectivity for isoindonlines. A chiral tertiary (3°)-benzylic position was not racemized during oxidation, and methyl indoprofen was prepared by late stage oxidation. Mechanistic studies suggest a selective H atom transfer, which avoids many known oxidation (by-)products of isoindolinones.
Functionalised dithiocarbamate complexes: Complexes based on indoline, indole and substituted piperazine backbones - X-ray crystal structure of [Ni(S2CNC3H6C6H4) 2]
Anastasiadis, Charalampos,Hogarth, Graeme,Wilton-Ely, James D.E.T.
experimental part, p. 3222 - 3228 (2011/02/15)
A range of new nickel, copper and zinc bis(dithiocarbamate) complexes has been prepared from secondary amines with functionalised backbones. These include complexes derived from iso-indoline, tetrahydro-isoindoline, 1,2,3,4-tetrahydroisoquinoline and a number of functionalised piperazines. The crystal structure of [Ni(S2CNC3H6C 6H4)2] derived from 1,2,3,4- tetrahydroisoquinoline is reported.
ROM-RCM of cycloalkene-yne
Kitamura, Tsuyoshi,Kuzuba, Yuichi,Sato, Yoshihiro,Wakamatsu, Hideaki,Fujita, Reiko,Mori, Miwako
, p. 7375 - 7389 (2007/10/03)
Ring-opening metathesis and ring-closing metathesis (ROM-RCM) of cycloalkene-yne was demonstrated using a first- or second-generation ruthenium complex. When cycloalkenes bearing the alkyne part at the C-3 position were reacted with a first-generation ruthenium-carbene complex under an atmosphere of ethylene, ROM-RCM proceeded smoothly to give skeletal reorganized products in good yields. In this reaction, cycloalkene-ynes having terminal alkyne were suitable. On the other hand, when cycloalkenes bearing the alkyne part at the C-1 position were treated with a second-generation ruthenium-carbene complex, ROM-RCM proceeded smoothly to give bicyclic compounds and/or dimeric compounds in good yields.
Ruthenium-Catalyzed ROM-RCM of Cycloalkene-yne
Mori, Miwako,Kuzuba, Yuichi,Kitamura, Tsuyoshi,Sato, Yoshihiro
, p. 3855 - 3858 (2007/10/03)
(Matrix Presented) ROM-RCM (ring-opening and ring-closing metatheses) of cycloalkene-yne was demonstrated using a second-generation ruthenium complex. When cycloalkene bearing the alkyne moiety at the C-1 position was reacted with a ruthenium-carbene complex under an atmosphere of ethylene, ROM-RCM proceeded smoothly to give bicyclic compound and/or dimeric compound in good yields.
Structural features of aliphatic N-nitrosamines of 7-azabicyclo[2.2.1]heptanes that facilitate N-NO bond cleavage
Ohwada,Miura,Tanaka,Sakamoto,Yamaguchi,Ikeda,Inagaki
, p. 10164 - 10172 (2007/10/03)
N-Nitrosamines can be considered as potential nitric oxide (NO)/nitrosonium ion (NO+) donors. However, the relation of the structures of N-nitrosamines, in particular of aliphatic N-nitrosamines, to the characteristics of release of NO or NO+ remains unclear. Here we show that aliphatic N-nitrosoamines of 7-azabicyclo[2.2.1]heptanes can undergo heterolytic N-NO bond cleavage. On the basis of the observation of reduced rotational barriers of the N-NO bonds in solution and nitrogen-pyramidal structures of the N-nitroso group in the solid state, we postulate that N-NO bond cleavage of N-nitrosamines is enhanced by a reduction of the resonance in the N-NO group. Computational studies suggest that these structural features of the N-nitrosamines of 7-azabicyclo[2.2.1]heptane are derived from angle strain imposed on the CNC angles.
Novel synthesis of heterocycles using nickel(0)-catalyzed [2+2+2] cocyclization: Catalytic asymmetric synthesis of isoindoline and isoquinoline derivatives
Sato, Yoshihiro,Nishimata, Toyoki,Mori, Miwako
, p. 443 - 457 (2007/10/03)
A nickel(0)-catalyzed asymmetric [2+2+2] cocyclization has been realized for the first time. That involves conceptually new enantiotopic group selective formation of the nickelacyclopentadiene (18) and produces the isoindoline (26a) (73percent ee, 78perce
Asymmetric synthesis of isoindoline and isoquinoline derivatives using nickel(0)-catalyzed [2 + 2 + 2] cocyclization
Sato,Nishimata,Mori
, p. 6133 - 6135 (2007/10/02)
A nickel(0)-catalyzed asymmetric [2 + 2 + 2] cocyclization has been realized for the first time, giving the isoindoline 16a in 73% ee (52% yield) and the isoquinoline 17b in 54% ee (62% yield), respectively.
Reaction of Tosylamide Monosodium Salt with Bis(halomethyl) Compounds: An Easy Entry to Symmetrical N-Tosyl Aza Macrocycles
Bottino, Francesco,Grazia, Michele Di,Finocchiaro, Paolo,Fronczek, Frank R.,Mamo, Antonino,Pappalardo, Sebastiano
, p. 3521 - 3529 (2007/10/02)
A one-step, general procedure for a variety of N-tosyl aza macrocycles (including aza-crown ethers, pyridino- and bipyridino-aza-crown analogues, and azacyclophanes), by reaction of appropriate bis(halomethyl) precursors with tosylamide monosodium salt (TsNHNa) in N,N-dimethylformamide, is described.In polymethyl-substituted 2,11-diazacyclophane systems, the methyl substituents play an important role in inducing stereospecific ring closures.Thus, coupling of 1,4-bis(chloromethyl)-2,5-dimethylbenzene (15b) with TsNHNa produced only one of the two possible diastereomeric dimers, to which chiral structure 16db was assigned by means of the chiral Eu(dcm)3 shift reagent.This stereochemical assignment was confirmed by a single-crystal X-ray study on 16d.Detosylation of N-tosyl aza macrocycles to the free polyamino macrocycles by reductive (Na-NH3) or hydrolytic (90percent H2SO4) methods, followed by N-methylation (CH2O-HCO2H), was also accomplished in excellent yield.The 1H NMR spectra of 2,11-diazacyclophanes and 2,11-diaza(2,6)pyridinophanes are discussed in terms of conformation and conformational mobility.
A VERSATILE ONE-POT SYNTHESIS OF SYMMETRICAL N-TOSYLAZAMACROCYCLES
Pappalardo, Sebastiano,Bottino, Francesco,Grazia, Michele Di,Finocchiaro, Paolo,Mamo, Antonino
, p. 1881 - 1884 (2007/10/02)
A variety of title compounds (azacrown ethers, pyridino-azacrown analogues and azacyclophanes) have been synthesized in moderate to good yield by coupling appropriate bis(halomethyl) or bis(tosylate ester) precursors with tosylamide monosodium salt.A revised mechanism is proposed.
