32394-86-8Relevant academic research and scientific papers
The synthesis and kinetic evaluation of aryl α-aminophosphonates as novel inhibitors of T. cruzi trans-sialidase
Chen, Zexin,Marcé, Patricia,Resende, Ricardo,Alzari, Pedro M.,Frasch, A. Carlos,van den Elsen, Jean M.H.,Crennell, Susan J.,Watts, Andrew G.
, p. 25 - 33 (2018)
The trans-sialidase protein expressed by Trypanosoma cruzi is an important enzyme in the life cycle of this human pathogenic parasite and is considered a promising target for the development of new drug treatments against Chagas' disease. Here we describe
Highly efficient one-pot multi-component synthesis of α- aminophosphonates and bis-α-aminophosphonates catalyzed by heterogeneous reusable silica supported dodecatungstophosphoric acid (DTP/SiO2) at ambient temperature and their antitubercular evaluation against Mycobactrium Tuberculosis
Mulla, Shafeek A. R.,Pathan, Mohsinkhan Y.,Chavan, Santosh S.,Gample, Suwara P.,Sarkar, Dhiman
, p. 7666 - 7672 (2014/02/14)
A highly efficient one-pot multi-component reaction (MCR) protocol over DTP/SiO2 has been developed for the synthesis of α- aminophosphonate derivatives (4a-x) in excellent yields. The α-aminophosphonate derivatives were for the first time evaluated for their antitubercular activity against the M. tuberculosis H37Ra (MTB) strain. An evaluation of the data on the cytotoxicity and antimicrobial activity shows that 4n and 4v are promising antitubercular agents.
