3240-96-8

Upstream product

• 27644-76-4 2-(p-methoxyphenyl)-4,4-dimethyloxazolidine 
• 64-04-0 phenethylamine 
• 63-91-2 L-phenylalanine 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 3241-00-7 N-(4-methoxybenzyl)-2-phenylethan-1-amine 
• 1018574-80-5 C₁₇H₁₈N₂O 
• 1421426-87-0 4-methoxy-N-phenethylbenzimidoyl cyanide 
• 632305-28-3 C₂₆H₂₁NO₄ 

Relevant academic research and scientific papers

Synthesis, spectral, structural and computational studies on NiS4 and NiS2NP chromophores: Anagostic and C-H?π (chelate) interactions in [Ni(dtc)(PPh3)(NCS)] (dtc = N-(2-phenylethyl)-N-(4-methoxybenzyl)- dithiocarbamate an

Bis(N-(2-phenylethyl)-N-substituted benzyldithiocarbamato-S,S′)nickel(II) (1-6) and (N-(2-phenylethyl)-N-substituted benzyldithiocarbamato-S,S′)(thiocyanato-N) (triphenylphosphine)nickel(II) (7-12) [substituted benzyl = 2HO-C6H4-CHs

Aromatic aldehyde-catalyzed gas-phase decarboxylation of amino acid anion via imine intermediate: An experimental and theoretical study

It is generally appreciated that carbonyl compound can promote the decarboxylation of the amino acid. In this paper, we have performed the experimental and theoretical investigation into the gas-phase decarboxylation of the amino acid anion catalyzed by the aromatic aldehyde via the imine intermediate on the basis of the tandem mass spectrometry (MS/MS) technique and density functional theory (DFT) calculation. The results show that the aromatic aldehyde can achieve a remarkable catalytic effect. Moreover, the catalytic mechanism varies according to the type of amino acid: (i) The decarboxylation of α-amino acid anion is determined by the direct dissociation of the C-C bond adjacent to the carboxylate, for the resulting carbanion can be well stabilized by the conjugation between α-carbon, C=N bond and benzene ring. (ii) The decarboxylation of non-α-amino acid anion proceeds via a SN2-like transition state, in which the dissociation of the C-C bond adjacent to the carboxylate and attacking of the resulting carbanion to the C=N bond or benzene ring take place at the same time. Specifically, for β-alanine, the resulting carbanion preferentially attacks the benzene ring leading to the benzene anion, because attacking the C=N bond in the decarboxylation can produce the unstable three or four-membered ring anion. For the other non-α-amino acid anion, the C=N bond preferentially participates in the decarboxylation, which leads to the pediocratic nitrogen anion.

Synthesis of iminonitriles by oxone/tbab-mediated one-pot oxidative three-component strecker reaction

Oxidative three-component reaction of aldehydes, amines, and TMSCN in a biphasic solvent system (toluene/H2O) containing Oxone, tetra-n-butylammonium bromide (TBAB) and sodium bicarbonate afforded α-iminonitriles in good to excellent yields. This oxidative Strecker reaction was applicable to a wide range of aldehydes and amines, aromatic or aliphatic, of different electronic and steric properties. Substituted 1-aza-2-cyano-1,3-dienes were also accessible using α,β-unsaturated aldehydes as inputs.

Synthesis of 2-alkyl-1-aryl-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione derivatives

A preparative procedure for the synthesis of 2-alkyl-1-aryl-1,2- dihydrochromeno[2,3-c]pyrrole-3,9-diones from methyl 4-(o-hydroxyphenyl)-2,4- dioxobutanoate, aromatic aldehyde, and aliphatic amine is described.

Synthesis of imines, diimines and macrocyclic diimines as possible ligands, in aqueous solution

Although it is recognized that the presence of water is disadvantageous for imine synthesis, we demonstrate that such synthesis can be effective in completely aqueous media, without any catalyst and under mild conditions. Thus, arylaryl, aryl-alkyl, alkyl-aryl and alkyl-alkyl monoimines as well as a large variety of diimines are obtained by direct condensation of the corresponding carbonyl compounds and amines, in water. The same process is used to synthesize macrocyclic diimines starting from methylene, ethylene, trimethylene and tetramethylene glycol bis(2-formylphenyl ether) and ethylene-, trimethylene- and tetramethylene-diamine, some of these macrocycles being known for their chelating properties.

Rapid purification of small molecule libraries by ion exchange chromatography

Amines and acylated amines are synthesized in traditional solution phase reactions, then rapidly purified by ion exchange chromatography to yield pure products. In some instances, impurities devoid of ionizable functionality can be covalently modified pri

Oxazolidines and thiazolidines as carbon transfer agents. Synthesis of tetrahydro-β-carboline and isoquinoline derivatives

Oxazolidines and thiazolidines transfer their C2 units to appropiate nucleophiles and furnish the corresponding tetrahydro-β-carboline and isoquinoline derivatives