324067-32-5Relevant academic research and scientific papers
The Synthesis of 1,3,5-triazine Derivatives and JNJ7777120 Analogues with Histamine H4 Receptor Affinity and Their Interaction with PTEN Promoter
Latacz, Gniewomir,Kechagioglou, Petros,Papi, Rigini,?a?ewska, Dorota,Wi?cek, Ma?gorzata,Kamińska, Katarzyna,Wencel, Przemys?aw,Karcz, Tadeusz,Schwed, Johannes S.,Stark, Holger,Kyriakidis, Dimitrios A.,Kie?-Kononowicz, Katarzyna
, p. 254 - 263 (2016)
The involvement of histamine and H4 receptor (H4R) in cancer has been investigated recently using the H4R agonists and antagonists. The scope of the research project was synthesis and exploration of the consequences of a g
A CO2-Catalyzed Transamidation Reaction
Yang, Yang,Liu, Jian,Kamounah, Fadhil S.,Ciancaleoni, Gianluca,Lee, Ji-Woong
, p. 16867 - 16881 (2021/11/18)
Transamidation reactions are often mediated by reactive substrates in the presence of overstoichiometric activating reagents and/or transition metal catalysts. Here we report the use of CO2as a traceless catalyst: in the presence of catalytic amounts of CO2, transamidation reactions were accelerated with primary, secondary, and tertiary amide donors. Various amine nucleophiles including amino acid derivatives were tolerated, showcasing the utility of transamidation in peptide modification and polymer degradation (e.g., Nylon-6,6). In particular,N,O-dimethylhydroxyl amides (Weinreb amides) displayed a distinct reactivity in the CO2-catalyzed transamidation versus a N2atmosphere. Comparative Hammett studies and kinetic analysis were conducted to elucidate the catalytic activation mechanism of molecular CO2, which was supported by DFT calculations. We attributed the positive effect of CO2in the transamidation reaction to the stabilization of tetrahedral intermediates by covalent binding to the electrophilic CO2
Iron/tetramethylethylenediamine-catalyzed ambient-temperature coupling of alkyl grignard reagents and aryl chlorides
Rushworth, Philip J.,Hulcoop, David G.,Fox, David J.
, p. 9517 - 9521 (2013/10/08)
Tetramethylethylenediamine (TMEDA) acts as cheap and readily removed ligand in the iron-catalyzed coupling of alkyl Grignard reagents and activated aryl chlorides. The use of TMEDA allows for low ligand and iron catalyst loading as well as an increased reaction concentration and an ambient reaction temperature on a mole scale.
