32412-39-8

Basic information

• Product Name: 1-(5-BROMO-THIOPHEN-2-YL)-PROPAN-1-ONE
• Synonyms: CHEMBRDG-BB 4303054;1-(5-BROMO-THIOPHEN-2-YL)-PROPAN-1-ONE;Nsc80373;1-(5-bromo-2-thienyl)propan-1-one(SALTDATA: FREE);1-(5-bromo-2-thienyl)propan-1-one
• CAS NO: 32412-39-8
• Molecular Formula: C₇H₇BrOS
• Molecular Weight: 219.1
• Mol File: 32412-39-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 291.2 °C at 760 mmHg
• Flash Point: 129.9 °C
• Appearance: /
• Density: 1.53 g/cm³
• Vapor Pressure: 0.00197mmHg at 25°C
• Refractive Index: 1.57
• CAS DataBase Reference: 1-(5-BROMO-THIOPHEN-2-YL)-PROPAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-BROMO-THIOPHEN-2-YL)-PROPAN-1-ONE(32412-39-8)
• EPA Substance Registry System: 1-(5-BROMO-THIOPHEN-2-YL)-PROPAN-1-ONE(32412-39-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 32412-39-8(Hazardous Substances Data)

Usage

General Description

1-(5-Bromo-thiophen-2-yl)-propan-1-one, also known as 5-bromo-2-thiophenylacetone, is a chemical compound with the molecular formula C8H7BrOS. It is a yellow to light brown liquid with a molecular weight of 217.1 g/mol. 1-(5-BROMO-THIOPHEN-2-YL)-PROPAN-1-ONE is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also utilized in organic synthesis to introduce the 5-bromo-2-thiophenylacetone group into various compounds, such as pyrazoles and pyrazolone derivatives. Additionally, 1-(5-Bromo-thiophen-2-yl)-propan-1-one is known for its potential medicinal properties, including antimicrobial and antifungal activity. Overall, this chemical is an important building block in the production of various valuable compounds and has potential applications in the pharmaceutical and agrochemical industries.

InChI:InChI=1/C7H7BrOS/c1-2-5(9)6-3-4-7(8)10-6/h3-4H,2H2,1H3

Upstream product

• 1003-09-4 2-bromothiophene 
• 79-03-8 propionyl chloride 
• 123-62-6 propionic acid anhydride 

Downstream Products

• 1013649-25-6 5-(5-bromothiophen-2-yl)-1-(2,4-dichloro-phenyl)-4-methyl-5-thiophen-2-yl-1H-pyrazole-3-carboxylic acid ethyl ester 

Relevant articles and documents

CYCLIC SULFAMIDE COMPOUNDS AND METHODS OF USING SAME

The present disclosure provides, in part, cyclic sulfamide compounds, and pharmaceutical compositions thereof, useful as modulators of Hepatitis B (HBV) core protein, and methods of treating Hepatitis B (HBV) infection.

A chemoselective α-aminoxylation of aryl ketones: a cross dehydrogenative coupling reaction catalysed by Bu4NI

Tetrabutyl ammonium iodide (TBAI) catalyzed α-aminoxylation of ketones using aq. TBHP as an oxidant has been accomplished. We have shown that the CDC (cross dehydrogenative coupling) reactions of ketones with N-hydroxyimidates such as N-hydroxysuccinimide (NHSI), N-hydroxyphthalimide (NHPI), N-hydroxybenzotriazole (HOBt) and 1-hydroxy-7-azabenzotriazole (HOAt) lead to the corresponding oxygenated products in good to moderate yields. The application of this method has been demonstrated by transforming a few coupled products into synthetically useful intermediates and products.

Hair growth stimulator property of thienyl substituted pyrazole carboxamide derivatives as a cb1 receptor antagonist with in vivo antiobesity effect

A few thienyl substituted pyrazole derivatives were synthesized to aid in the characterization of the cannabinoid receptor antagonist and also to serve as potentially useful antiobesity agent. Structural requirements for selective CB1 receptor antagonistic activity of 5-thienyl pyrazole derivatives included the structural similarity with potent, specific antagonist rimonabant 1. Compound 3 has been identified as a hair growth stimulator and an antiobesity agent in animal models.