3244-54-0Relevant articles and documents
Synthesis and memory characteristics of novel soluble polyimides based on asymmetrical diamines containing carbazole
Zhao, Jing,Peng, Ling,Zhu, Ya-Liang,Song, Yang-Jun,Wang, Li-Jun,Shen, Ying-Zhong
, p. 118 - 127 (2016)
Two novel asymmetrical carbazole-based diamines 9-(2-(1,1′-binaphthyl-4-yl)benzyl)-9H-carbazole-3,6-diamine (BNBCD) and 9-((4′-(9H-carbazol-9-yl)biphenyl-2-yl)methyl-9H-carbazole-3,6-diamine (CBMCD) were synthesized. A series of novel soluble aromatic polyimides were prepared from these diamines by poly-condensation with Pyromelitic dianhydride (PMDA) and 2,2′,3,3′-biphenyl tetracarboxylic dianhydride (BPDA) via a two-step procedure. The resulting polymers were fully characterized, they exhibited excellent organosolubility and high thermal stability with the temperature of 5% weight loss under nitrogen atmosphere over 400°C. Resistive switching devices with the configuration of Al/polymer/ITO were constructed from these polyimides by using conventional solution coating process. The memory devices based on PI-a, PI-b and PI-c exhibited a flash type memory capability, whereas the PI-d presented a write once read many times (WORM) memory capability.
Disubstituted 1,8-dipyrazolcarbazole derivatives as a new type of c-myc G-quadruplex binding ligands
Chen, Wei-Jia,Zhou, Chen-Xi,Yao, Pei-Fen,Wang, Xiao-Xiao,Tan, Jia-Heng,Li, Ding,Ou, Tian-Miao,Gu, Lian-Quan,Huang, Zhi-Shu
, p. 2829 - 2836 (2012)
A series of 1,8-dipyrazolcarbazole (DPC) derivatives (6a-6d, 7a-7d) designed as G-quadruplex ligands have been synthesized and characterized. The FRET-melting and SPR results showed that the DPC derivatives could well recognize G-quadruplex with strong discrimination against the duplex DNA. In addition, the DPC derivatives showed much stronger stabilization activities and binding affinities for c-myc G-quadruplex rather than telomeric G-quadruplex. Therefore, their interactions with c-myc G-quadruplex were further explored by means of CD spectroscopy, PCR-stop assay, and molecular modeling. In cellular studies, all compounds showed strong cytotoxicity against cancer cells, while weak cytotoxicity towards normal cells. RT-PCR assay showed that compound 7b could down-regulate c-myc gene expression in Ramos cell line, while had no effect on c-myc expression in CA46 cell line with NHE III1 element removed, indicating its effective binding with G-quadruplex on c-myc oncogene in vivo.
Carbazole triamine derivative and preparation method and application thereof
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Paragraph 0070; 0075-0078, (2021/08/06)
The invention discloses a carbazole triamine derivative and a preparation method thereof. The carbazole triamine derivative has a structure shown in the following formula. The preparation method of the carbazole triamine derivative is easy to operate, raw materials are easy to obtain, the price is low, the purity is extremely high, and the reaction yield is very high; the carbazole triamine derivative prepared by the method has wide application prospects in the fields of medicine, biology, luminescent materials and the like.
Carbazole as Linker for Dinuclear Gadolinium-Based MRI Contrast Agents
Mousavi, Bibimaryam,Chauvin, Anne-Sophie,Moriggi, Lo?ck,Helm, Lothar
, p. 5403 - 5412 (2017/12/18)
Ligands able to complex two gadolinium ions have been synthesized and characterized in view of the ability of the complexes to increase the spin relaxation of water protons. All ligands are based on the heptadentate diethylenetriaminetetraacetic acid (DTTA) chelator and carbazole as a rigid linker. Depending on the derivatization on the nitrogen atom of the five-membered ring, the compounds form small aggregates in aqueous solution, self-assemble to form micelles or bind to human serum albumin. In all cases, this leads to a marked increase in 1H relaxivity at nuclear Larmor frequencies between 20 and 60 MHz. Water exchange on the gadolinium ions as measured by 17O NMR relaxation is fast enough not to limit relaxivity. 1H nuclear magnetic relaxation dispersion profiles were also measured and analyzed using Solomon–Bloembergen–Morgan theory including Lipari–Szabo treatment to include internal motion or anisotropic rotation.