32446-66-5

Basic information

• Product Name: N-(2-AMINO-BENZOTHIAZOL-6-YL)-ACETAMIDE
• Synonyms: AKOS BB-8277;4,4'-DICYANOBENZOPHENONE;ASISCHEM Z25293;IFLAB-BB F0909-0068;N-(2-AMINO-1,3-BENZOTHIAZOL-6-YL)ACETAMIDE;N-(2-AMINOBENZO[D]THIAZOL-6-YL) ACETAMIDE;N-(2-AMINO-BENZOTHIAZOL-6-YL)-ACETAMIDE;4,4'-Carbonylbis-benzonitrile
• CAS NO: 32446-66-5
• Molecular Formula: C₁₅H₈N₂O
• Molecular Weight: 232.24
• EINECS: 1533716-785-6
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 32446-66-5.mol
• Article Data: 21

Chemical Properties

• Melting Point: 162 °C
• Boiling Point: 457.782 °C at 760 mmHg
• Flash Point: 230.658 °C
• Appearance: /
• Density: 1.267 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• CAS DataBase Reference: N-(2-AMINO-BENZOTHIAZOL-6-YL)-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-AMINO-BENZOTHIAZOL-6-YL)-ACETAMIDE(32446-66-5)
• EPA Substance Registry System: N-(2-AMINO-BENZOTHIAZOL-6-YL)-ACETAMIDE(32446-66-5)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 32446-66-5(Hazardous Substances Data)

Usage

Chemical Properties

Light Brown Solid

Uses

Letrozole intermediate.

Upstream product

• 74032-49-8 S-(2-pyridinyl) 4-cyanobenzenecarbothioate 
• 623-00-7 4-bromobenzenecarbonitrile 
• 108-24-7 acetic anhydride 
• 98-86-2 acetophenone 
• 134521-16-7 4,4'-Methanol-bisbenzonitrile 
• 108-94-1 cyclohexanone 
• 3988-03-2 bis(4-bromophenyl)methanone 
• 76590-50-6 2-(4-cyanophenyl)-2-oxoacetic acid 
• 64-18-6 formic acid 
• 3058-39-7 4-iodobenzonitrile 
• 105-07-7 4-cyanobenzaldehyde 
• 201230-82-2 carbon monoxide 
• 126747-14-6 4-cyanophenylboronic acid 
• 611-97-2 bis(p-methylphenyl)-methanone 

Downstream Products

• 127222-97-3 C₂₄H₁₆N₂O₂ 
• 112809-51-5 letrozol 
• 134521-17-8 bis(4-cyanophenyl)methylmethanesulfonate 
• 64568-33-8 4-[(4-cyanophenyl)(diazo)methyl]benzonitrile 
• 10605-45-5 1,1-di(4-cyanophenyl)-ethylene 

Relevant articles and documents

Base-free oxidation of alcohols enabled by nickel(ii)-catalyzed transfer dehydrogenation

An efficient nickel(ii)-catalyzed transfer dehydrogenation oxidation of alcohols is reported that relies on cyclohexanone as the formal oxidant and does not require the use of an external base. The synthetic utility of this protocol is demonstratedviathe facile oxidation of structurally complicated natural products.

A novel process for the synthesis of substantially pure Letrozole

This article demonstrates an improved novel and practical synthesis of oral non-steroidal aromatase inhibitor (AI) Letrozole in a five-stage synthetic process in excellent yields. Key steps of the synthesis involve the condensation of 4-(chloro(4-cyanophenyl)methyl)benzamide with 1H-1,2,4-triazole and further its dehydration to Letrozole by using trifluoroacetic anhydride at low temperature.