32449-07-3Relevant academic research and scientific papers
Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance
Tarnchompoo, Bongkoch,Chitnumsub, Penchit,Jaruwat, Aritsara,Shaw, Philip J.,Vanichtanankul, Jarunee,Poen, Sinothai,Rattanajak, Roonglawan,Wongsombat, Chayaphat,Tonsomboon, Aunchalee,Decharuangsilp, Sasithorn,Anukunwithaya, Tosapol,Arwon, Uthai,Kamchonwongpaisan, Sumalee,Yuthavong, Yongyuth
supporting information, p. 1235 - 1240 (2019/01/04)
The S108N mutation of dihydrofolate reductase (DHFR) renders Plasmodium falciparum malaria parasites resistant to pyrimethamine through steric clash with the rigid side chain of the inhibitor. Inhibitors with flexible side chains can avoid this clash and
Analysis and improvement of an anion-templated rotaxane synthesis
Schalley, Christoph A.,Silva, Gabriele,Nising, Carl Friedrich,Linnartz, Petra
, p. 1578 - 1596 (2007/10/03)
A series of new rotaxanes with axles different in length was prepared. Following the synthetic protocol utilizing a known anion template effect (Scheme 1), surprisingly low yields in the order of 2 - 5% were obtained (Scheme 3), which furthermore signific
Molecular Recognition of Neutral Molecules by Metalloclefts: Synthesis, X-ray Structure, 1H NMR Spectroscopy, Electrochemistry, and Molecular Modeling
Doorn, Arie R. van,Bos, Martinus,Harkema, Sybolt,Eerden, Johan van,Verboom, Willem,Reinhoudt, David N.
, p. 2371 - 2380 (2007/10/02)
Metalloclefts 2 and 10a-b and metallomacrocycles 7a-c possessing a Lewis acidic uranyl cation were synthesized from the corresponding aldehydes.The complexation of these compounds with neutral molecules was assessed by 1H NMR spectroscopy, X-ray structure
