324526-82-1

Basic information

• Product Name: 2-(4-fluorophenyl)-7-methyl-4H-chromen-4-one
• Synonyms: 2-(4-fluorophenyl)-7-methyl-4H-chromen-4-one
• CAS NO: 324526-82-1
• Molecular Weight: 254.261
• Mol File: 324526-82-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(4-fluorophenyl)-7-methyl-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluorophenyl)-7-methyl-4H-chromen-4-one(324526-82-1)
• EPA Substance Registry System: 2-(4-fluorophenyl)-7-methyl-4H-chromen-4-one(324526-82-1)

Safety Data

• Hazardous Substances Data: 324526-82-1(Hazardous Substances Data)

Upstream product

• 766-98-3 1-ethynyl-4-fluorobenzene 
• 706-06-9 3-(4-flurophenyl)prop-2-ynoic acid 
• 459-57-4 4-fluorobenzaldehyde 
• 159957-00-3 1-(2,2-dibromovinyl)-4-fluorobenzene 
• 6921-64-8 4'-hydroxy-2'-methylacetophenone 
• 1219977-58-8 C₁₆H₁₃FO₂ 

Downstream Products

• 1219977-50-0 C₁₆H₁₁FOS 

Relevant articles and documents

A 2 - aryl flavone preparation method

The invention discloses a 2 - aryl flavone preparation method, including: in the silver catalyst and under the action of the oxidizing agent, ortho-hydroxy aryl formyl formic acid and aryl alkynoic ring reaction in a solvent, after the reaction is finished after treatment to obtain the 2 - aryl flavone. The method of this invention easily obtained and cheap agents, mild reaction conditions, reaction functional group compatibility is good, cheap catalyst, the catalytic system is simple.

Pd catalyzed couplings of “superactive esters” and terminal alkynes: Application to flavones and γ-benzopyranones construction

Lewis base, N-methylmorpholine (NMM) accelerated Pd-catalyzed Sonogashira coupling of steric hindered super active esters, 1a–1e, and terminal alkynes. This approach provided an efficient synthetic protocol for a broad array of acylated o-alkynoylphenols compounds, 3a–3e, under moderate conditions. The mechanistic study clearly demonstrated that NNM stabilized the catalytic palladium species, and accelerated the leaving of triazine moiety during the catalytic cycle of the cross-coupling reactions. In addition, piperazine was found to efficiently catalyze the 6-endo cyclization of acylated o-alkynoylphenols, which achieved the diversity oriented synthesis of γ-benzopyranones, 4aa–4eg, with 93–99% yields.