3247-75-4

Usage

Uses

Used in Pharmaceutical Industry:
3-(3-hydroxyphenyl)-3-hydroxypropanoic acid is used as a pharmaceutical compound for its potential health benefits. As a urinary metabolite of phenylalanine and Rutin, it may contribute to the maintenance of capillary health and the regulation of phenylalanine metabolism in the body.
Used in Research Applications:
3-(3-hydroxyphenyl)-3-hydroxypropanoic acid is used as a research compound for studying its properties, potential applications, and interactions with biological systems. Its unique structure and functional groups make it a valuable tool for investigating various biological processes and mechanisms.

InChI:InChI=1/C9H10O4/c10-7-3-1-2-6(4-7)8(11)5-9(12)13/h1-4,8,10-11H,5H2,(H,12,13)

Upstream product

• 87877-89-2 β-m-benzyloxyphenylhydracrylic acid 

Downstream Products

• 3247-75-4 (R)-3-hydroxy-3-(3-hydroxy-phenyl)-propionic acid 
• 17430-96-5 (S)-3-hydroxy-3-(3-hydroxy-phenyl)-propionic acid 

Relevant academic research and scientific papers

Studies on drug metabolism by use of isotopes. XXVI. Determination of urinary metabolites of rutin in humans

Determination of urinary metabolites of orally administered rutin and rutin-2',5',6'-d3 in humans was carried out by TLC and GLC-mass spectrometry. In human urine, 3-hydroxyphenylacetic acid, 3-methoxy-4-hydroxyphenylacetic acid, 3,4-dihydroxyphenylacetic acid, 3,4-dihydroxytoluene, and β-m-hydroxyphenylhydracrylic acid were identified as rutin metabolites. Unchanged rutin and quercetin were not present in the urine.

Studies on drug metabolism by use of isotopes. XXVII: Urinary metabolites of rutin in rats and the role of intestinal microflora in the metabolism of rutin

Analysis of urinary metabolites of orally administered rutin (I) labeled with deuterium ([2,5',6'-2H]rutin, rutin-d) was carried out by GLC-MS. In rat urine, 3-hydroxyphenylacetic acid (III), 3-methoxy-4-hydroxyphenylacetic acid (IV), 3,4-dihydroxyphenylacetic acid (V), 3,4-dihydroxytoluene (VI), and 3-(m-hydroxyphenyl)propionic acid (VIII) were identified as rutin metabolites and were differentiated from the corresponding endogeneous compounds. Unchanged I and quercetin (II) were not present in the urine. Rutin-d was injected intraperitoneally in rats, administered orally to neomycin-treated rats, and incubated in vitro with the intestinal contents of rats. The experiments suggested the involvement of intestinal microflora in the metabolism of orally administered I.