Studies on drug metabolism by use of isotopes. XXVI. Determination of urinary metabolites of rutin in humans

DOI: 10.1002/jps.2600700717

Source and publish data:

Journal of Pharmaceutical Sciences p. 780 - 782 (1981)

Update date:2022-08-11

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Authors:

Baba Baba

Furuta Furuta

Horie Horie

Nakagawa

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Article abstract of DOI:10.1002/jps.2600700717

Determination of urinary metabolites of orally administered rutin and rutin-2',5',6'-d₃ in humans was carried out by TLC and GLC-mass spectrometry. In human urine, 3-hydroxyphenylacetic acid, 3-methoxy-4-hydroxyphenylacetic acid, 3,4-dihydroxyphenylacetic acid, 3,4-dihydroxytoluene, and β-m-hydroxyphenylhydracrylic acid were identified as rutin metabolites. Unchanged rutin and quercetin were not present in the urine.

Full text of DOI:10.1002/jps.2600700717

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