324737-45-3Relevant academic research and scientific papers
Solid phase parallel synthesis of tertiary amines
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Page/Page column 4, (2008/06/13)
Described is method for preparing tertiary amines comprising sequential, exhaustive alkylation of a hydroxylamine derivative and cleavage of the O—N bond using the following steps: a) reacting the hydroxylamine derivative with an alkylating agent or with
General combinatorial synthesis of tertiary amines on solid support. A novel conditional release strategy based on traceless linking at nitrogen
Gustafsson, Magnus,Olsson, Roger,Andersson, Carl-Magnus
, p. 133 - 136 (2007/10/03)
A novel solid phase synthesis of tertiary amines involving iodide-induced cleavage of the N-O bond of resin bound alkoxyammonium intermediates is described. The quaternary intermediates were assembled via sequential reductive aminations followed by alkylation. Cleavage from the solid support was induced by iodide ion or base, to afford the target tertiary amines in excellent purity.
