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324769-11-1

2-BROMO-1-FLUORO-3-(METHOXYMETHOXY)BENZENE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 324769-11-1 Structure

  • Basic information

    1. Product Name: 2-BROMO-1-FLUORO-3-(METHOXYMETHOXY)BENZENE
    2. Synonyms: 2-BROMO-1-FLUORO-3-(METHOXYMETHOXY)BENZENE
    3. CAS NO:324769-11-1
    4. Molecular Formula: C8H8BrFO2
    5. Molecular Weight: 235.05
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 324769-11-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-BROMO-1-FLUORO-3-(METHOXYMETHOXY)BENZENE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-BROMO-1-FLUORO-3-(METHOXYMETHOXY)BENZENE(324769-11-1)
    11. EPA Substance Registry System: 2-BROMO-1-FLUORO-3-(METHOXYMETHOXY)BENZENE(324769-11-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 324769-11-1(Hazardous Substances Data)

324769-11-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 324769-11-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,4,7,6 and 9 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 324769-11:
(8*3)+(7*2)+(6*4)+(5*7)+(4*6)+(3*9)+(2*1)+(1*1)=151
151 % 10 = 1
So 324769-11-1 is a valid CAS Registry Number.

324769-11-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(methoxymethoxy)-2-bromo-3-fluorobenzene

1.2 Other means of identification

Product number -
Other names 2-BROMO-1-FLUORO-3-(METHOXYMETHOXY)BENZENE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:324769-11-1 SDS

324769-11-1Relevant articles and documents

Four-ring-fused compound as well as preparation method and application thereof

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Paragraph 0415; 0439-0442, (2021/02/10)

The invention discloses a compound shown as a formula (I), an optical isomer and pharmacologically acceptable salts thereof, and application of the compound as a KRAS inhibitor.

KRAS G12C INHIBITORS

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Paragraph 0220, (2020/07/25)

The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with in Vivo Activity

Fell, Jay B.,Fischer, John P.,Baer, Brian R.,Ballard, Joshua,Blake, James F.,Bouhana, Karyn,Brandhuber, Barbara J.,Briere, David M.,Burgess, Laurence E.,Burkard, Michael R.,Chiang, Harrah,Chicarelli, Mark J.,Davidson, Kevin,Gaudino, John J.,Hallin, Jill,Hanson, Lauren,Hee, Kenneth,Hicken, Erik J.,Hinklin, Ronald J.,Marx, Matthew A.,Mejia, Macedonio J.,Olson, Peter,Savechenkov, Pavel,Sudhakar, Niranjan,Tang, Tony P.,Vigers, Guy P.,Zecca, Henry,Christensen, James G.

supporting information, p. 1230 - 1234 (2018/12/11)

KRAS is the most frequently mutated driver oncogene in human cancer, and KRAS mutations are commonly associated with poor prognosis and resistance to standard treatment. The ability to effectively target and block the function of mutated KRAS has remained elusive despite decades of research. Recent findings have demonstrated that directly targeting KRAS-G12C with electrophilic small molecules that covalently modify the mutated codon 12 cysteine is feasible. We have discovered a series of tetrahydropyridopyrimidines as irreversible covalent inhibitors of KRAS-G12C with in vivo activity. The PK/PD and efficacy of compound 13 will be highlighted.

SEROTONERGIC BENZOTHIOPHENES

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Page 19, (2010/02/08)

The present invention provides serotonergic benzothiophenes of Formula (I), where A, R, R, R, R, and R are as described in the specification.

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