443-81-2

Basic information

• Product Name: 2-Bromo-3-fluorophenol
• Synonyms: 2-BROMO-3-FLUOROPHENOL;3-Fluoro-2-bromophenol;Bromo-3-fluorophenol
• CAS NO: 443-81-2
• Molecular Formula: C₆H₄BrFO
• Molecular Weight: 191
• Product Categories: Aromatic Phenols;pharmacetical;Phenol&Thiophenol&Mercaptan;Aromatics, Miscellaneous Reagents
• Mol File: 443-81-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 196.141 °C at 760 mmHg
• Flash Point: 72.424 °C
• Appearance: light yellow liquid
• Density: 1.764 g/cm³
• Vapor Pressure: 0.288mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 7.43±0.10(Predicted)
• CAS DataBase Reference: 2-Bromo-3-fluorophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-3-fluorophenol(443-81-2)
• EPA Substance Registry System: 2-Bromo-3-fluorophenol(443-81-2)

Safety Data

• Hazard Codes: T,Xn
• Statements: 20/21/22-36/37/38-22
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 443-81-2(Hazardous Substances Data)

Usage

Chemical Properties

light yellow liquid

Uses

2-Bromo-3-fluorophenol has been used as a reactant in the preparation of diaryl ethers.

InChI:InChI=1/C6H4BrFO/c7-6-4(8)2-1-3-5(6)9/h1-3,9H

Upstream product

• 126940-10-1 1-fluoro-3-(methoxy-methoxy)benzene 
• 64248-56-2 1-bromo-2,6-difluorobenzene 
• 446-59-3 2‐bromo‐1‐fluoro‐3‐methoxybenzene 
• 205187-05-9 3-fluorophenyl N,N-diethyl-O-carbamate 
• 863870-75-1 O-2-bromo-3-fluorophenyl N,N-diethylcarbamate 
• 372-20-3 3-fluorophenol 
• 7664-93-9 sulfuric acid 

Downstream Products

• 7657-28-5 3-bromo-2-fluoro-4-hydroxy-benzaldehyde 
• 856076-73-8 3-bromo-4-fluoro-2-hydroxy-benzaldehyde 
• 324769-12-2 O-(3-fluoro-2-bromophenyl)-N,N-diethylthiocarbamate 
• 324769-09-7 (6-fluorobenzothien-7-yl)boronic acid 
• 324769-14-4 2-(3-fluoro-2-bromophenylthio)acetaldehyde diethylacetal 
• 324769-13-3 S-(3-fluoro-2-bromophenyl)-N,N-diethylthiocarbamate 
• 1239492-22-8 2-bromo-1-(difluoromethoxy)-3-fluorobenzene 

Relevant articles and documents

Approaches to the synthesis of 2,3-dihaloanilines. Useful precursors of 4-functionalized-1 H-indoles

2,3-Dihaloanilines have been proved as useful starting materials for synthesizing 4-halo-1H-indoles. Subsequent or in situ functionalization of the prepared haloindoles allows the access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles in good overall yields. As no efficient synthetic routes to 2,3-dihaloanilines have been described in the literature, different approaches to the preparation of these 1,2,3-functionalized aromatic precursors are now presented. The most general one involves a Smiles rearrangement from the corresponding 2,3-dihalophenols and allows the preparation of 2,3-dihaloanilides in a straightforward and synthetically useful manner.

An efficient, rapid, and regioselective bromination of anilines and phenols with 1-butyl-3-methylpyridinium tribromide as a new reagent/solvent under mild conditions

1-Butyl-3-methylpyridinium tribromide, [BMPy]Br3 proves to be a highly efficient, regioselective reagent/solvent for nuclear bromination of various anilines and phenols. The synthesis and characterization of the room temperature ionic liquid [BMPy]Br3 (2) is described. The bromination was carried out in the absence of organic solvents and in most cases the only extraction solvent needed was water. The spent 1-butyl-3-methylpyridinium bromide (1) was easily recycled.

SEROTONERGIC BENZOTHIOPHENES

The present invention provides serotonergic benzothiophenes of Formula (I), where A, R, R, R, R, and R are as described in the specification.