32487-58-4

Usage

Uses

Used in Food Industry:
3-Methoxy-2-furfuraldehyde is used as a food additive and flavoring agent for its sweet and caramel-like taste, enhancing the flavor profiles of various food products.
Used in Chemical Industry:
3-Methoxy-2-furfuraldehyde is used as a bio-based platform chemical for the production of various value-added chemicals and biofuels, contributing to the development of sustainable and eco-friendly alternatives to traditional petrochemicals.
Used in Pharmaceutical and Medical Research:
3-Methoxy-2-furfuraldehyde is being investigated for its antioxidant properties and potential health benefits, making it a subject of interest in pharmaceutical and medical research. Its potential applications in this field are still under exploration, but the compound's unique properties offer promising avenues for future discoveries and applications.

Upstream product

• 3420-57-3 furan-3-methanol 
• 68-12-2 N,N-dimethyl-formamide 
• 14757-78-9 3-bromofurfural 
• 124-41-4 sodium methylate 

Relevant academic research and scientific papers

An expedient route to 3-methoxy-2-furaldehyde

An expedient route to 3-methoxy-2-furaldehyde is presented. Georg Thieme Verlag Stuttgart. New York.

SYNTHESIS OF ENONE INTERMEDIATE

The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides a more efficient route for preparing the enone intermediate.

A practical, enantioselective synthetic route to a key precursor to the tetracycline antibiotics

A practical, enantioselective synthetic route to a key precursor to the tetracycline antibiotics is reported. The route proceeds in nine steps (21% yield) from the commercial substance methyl 3-hydroxy-5-isoxazolecarboxylate. Key steps in the route involve enantioselective addition of divinylzinc to 3-benzyloxy-5-isoxazolecarboxaldehyde and an endo-selective intramolecular furan Diels-Alder cycloaddition reaction. The route described has provided more than 40 g of chromatographically pure 1 with 93% ee.